Raquel Fucho

TL;DR: The depletion of SAM and GSH in mitochondria is an early event in the MCD model of NASH, which is determined by the lack of methionine, and therapy using permeable GSH prodrugs may be of relevance in NASH.

TL;DR: Enhanced FAO in palmitate-incubated adipocytes and macrophages reduced triglyceride content and inflammation, improved insulin sensitivity in adipocytes, and reduced endoplasmic reticulum stress and ROS damage in Macrophages indicates that enhancingFAO in metabolically relevant cells such as adipocyte andmacrophages may be a promising strategy for the treatment of chronic inflammatory pathologies such as obesity and type 2 diabetes.

TL;DR: This review highlights the mechanisms of fatty acid uptake, trafficking and oxidation in brown fat thermogenesis and focuses on BAT's morphological and functional characteristics and fatty acid synthesis, storage, oxidation and use as a source of energy.

TL;DR: In vivo pharmacological ASMase inhibition by amitriptyline protected wild type mice against HFD-induced hepatic steatosis, fibrosis, and liver damage, effects indicative of early-stage NASH.

TL;DR: The data indicate that ASMase is critical for alcohol-induced ER stress, and provide a rationale for further clinical investigation in ALD.