L
Laurent Dubuquoy
Researcher at university of lille
Publications - 114
Citations - 7103
Laurent Dubuquoy is an academic researcher from university of lille. The author has contributed to research in topics: Colitis & Inflammatory bowel disease. The author has an hindex of 35, co-authored 95 publications receiving 6168 citations. Previous affiliations of Laurent Dubuquoy include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.
Christel Rousseaux,Xavier Thuru,Xavier Thuru,Agathe Gelot,Nicolas Barnich,Christel Neut,Christel Neut,Laurent Dubuquoy,Laurent Dubuquoy,Caroline Dubuquoy,Caroline Dubuquoy,Emilie Mérour,Emilie Mérour,Karen Geboes,Mathias Chamaillard,Mathias Chamaillard,Arthur C. Ouwehand,Greg Leyer,Didier Carcano,Jean-Frederic Colombel,Jean-Frederic Colombel,Denis Ardid,Pierre Desreumaux,Pierre Desreumaux +23 more
TL;DR: It is found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine.
Rousseaux C, Thuru X, Gelot A, et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Christel Rousseaux,Xavier Thuru,Agathe Gelot,Nicolas Barnich,Christel Neut,Laurent Dubuquoy,Caroline Dubuquoy,Emilie Mérour,Karen Geboes,Mathias Chamaillard,Arthur C. Ouwehand,Greg Leyer,Didier Carcano,Jean-Frederic Colombel,Denis Ardid,Pierre Desreumaux +15 more
TL;DR: The authors found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut.
Journal ArticleDOI
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.
Pierre Desreumaux,Laurent Dubuquoy,Sophie Nutten,Michel Peuchmaur,Walter Englaro,Kristina Schoonjans,Benoit Dérijard,Béatrice Desvergne,Walter Wahli,Pierre Chambon,Mark D. Leibowitz,Jean-Frederic Colombel,Johan Auwerx +12 more
TL;DR: It is demonstrated that activation of the RXR/PPARγ heterodimer protects against colon inflammation and suggested that combination therapy with both RXR and PPARγ ligands might hold promise in the clinic due to their synergistic effects.
Journal ArticleDOI
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
Christel Rousseaux,Bruno Lefebvre,Laurent Dubuquoy,Philippe Lefebvre,Olivier Romano,Johan Auwerx,Daniel Metzger,Walter Wahli,Béatrice Desvergne,Gian Carlo Naccari,Philippe Chavatte,Amaury Farce,Philippe Bulois,Antoine Cortot,Jean-Frederic Colombel,Pierre Desreumaux +15 more
TL;DR: PPAR-γ is identified as a target of 5-ASA underlying antiinflammatory effects in the colon, and its activities are associated with the recruitment of coactivators and the activation of a peroxisome-proliferator response element–driven gene.
Journal ArticleDOI
Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis
Laurent Dubuquoy,Emmelie Å. Jansson,Samir S. Deeb,Sabine Rakotobe,Mehdi Karoui,Jean-Frederic Colombel,Johan Auwerx,Sven Pettersson,Pierre Desreumaux +8 more
TL;DR: Data showed that the commensal intestinal flora affects the expression of PPARγ and thatPPARγ expression is considerably impaired in patients with UC, 2 inflammatory bowel diseases resulting from an abnormal immune response to bacterial antigens.