Lulu Xie

TL;DR: It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

TL;DR: Evaluating the efficiency of CSF–ISF exchange and interstitial solute clearance is impaired in the aging brain found that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways.

TL;DR: It is shown that the synchronized release of norepinephrine from locus coeruleus projections throughout the cerebral cortex mediate long-ranging Ca2+ signals by activation of astrocytic α1-adrenergic receptors, which may coordinate the broad effects of neuromodulators on neuronal activity.

TL;DR: It is shown, using 2-photon imaging of a near-infrared 2-deoxyglucose analogue (2DG-IR), that glucose is taken up preferentially by neurons in awake behaving mice, and the neuron is identified as the principal locus of glucose uptake as visualized by functional brain imaging.

TL;DR: High-resolution 3D magnetic resonance imaging, diffusion-weighted MR imaging, and intravoxel-incoherent motion DWI are used to evaluate glymphatic function and may serve as valuable translational biomarker to study glymphatics in human disease.