C
Chengjin Ye
Researcher at Texas Biomedical Research Institute
Publications - 60
Citations - 1590
Chengjin Ye is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 28 publications receiving 455 citations. Previous affiliations of Chengjin Ye include University of Rochester.
Papers
More filters
Journal ArticleDOI
SARS-CoV-2 spike E484K mutation reduces antibody neutralisation.
Sonia Jangra,Chengjin Ye,Raveen Rathnasinghe,Daniel Stadlbauer,Florian Krammer,Viviana Simon,Luis Martinez-Sobrido,Adolfo García-Sastre,Michael Schotsaert +8 more
Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Posted ContentDOI
The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.
Sonia Jangra,Chengjin Ye,Raveen Rathnasinghe,Daniel Stadlbauer,Florian Krammer,Viviana Simon,Luis Martinez-Sobrido,Adolfo García-Sastre,Michael Schotsaert +8 more
TL;DR: In this article, the E484K mutation in the spike RBD was found to leave vaccinees less protected against newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Journal ArticleDOI
Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome
Chengjin Ye,Kevin Chiem,Jun-Gyu Park,Fatai S. Oladunni,Fatai S. Oladunni,Roy N. Platt,Tim J. Anderson,Fernando Almazán,Juan Carlos de la Torre,Luis Martinez-Sobrido +9 more
TL;DR: This is the first description of a BAC-based reverse genetics system for the generation of infectious rSARS-CoV-2 that displays features in vivo similar to those of a natural viral isolate and will facilitate studies addressing several important questions in the biology of SARS- CoV- 2.