A
Anastasija Cupic
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 10
Citations - 589
Anastasija Cupic is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 4 publications receiving 221 citations.
Papers
More filters
Journal ArticleDOI
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Lisa Miorin,Thomas Kehrer,Maria Teresa Sánchez-Aparicio,Ke Zhang,Phillip Cohen,Roosheel S. Patel,Anastasija Cupic,Tadashi Makio,Menghan Mei,Elena Moreno,Oded Danziger,Kris M. White,Raveen Rathnasinghe,Melissa B. Uccellini,Shengyan Gao,Teresa Aydillo,Ignacio Mena,Xin Yin,Laura Martin-Sancho,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Sumit K. Chanda,Michael Schotsaert,Richard W. Wozniak,Yi Ren,Brad R. Rosenberg,Beatriz M. A. Fontoura,Adolfo García-Sastre +28 more
TL;DR: SARS-CoV-2 is able to efficiently block STAT1 and STAT2 nuclear translocation in order to impair transcriptional induction of IFN-stimulated genes (ISGs).
Posted ContentDOI
The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera
Raveen Rathnasinghe,Sonia Jangra,Anastasija Cupic,Carles Martínez-Romero,Lubbertus C. F. Mulder,Thomas Kehrer,Soner Yildiz,Angela Choi,Ignacio Mena,Jana De Vrieze,Sadaf Aslam,Daniel Stadlbauer,David A. Meekins,Chester McDowell,Velmurugan Balaraman,Juergen A. Richt,Bruno G. De Geest,Lisa Miorin,Florian Krammer,Viviana Simon,Adolfo García-Sastre,Michael Schotsaert +21 more
TL;DR: In this paper, a mouse-adapted SARS-CoV-2 was serial passed through a clinical virus isolate in the lungs of mice and then used low doses of this virus in mouse models for advanced age, diabetes and obesity.
Journal ArticleDOI
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice.
Jesus Silvas,Desarey Morales Vasquez,Jun-Gyu Park,Kevin Chiem,Anna Allué-Guardia,Andreu Garcia-Vilanova,Roy N. Platt,Lisa Miorin,Thomas Kehrer,Anastasija Cupic,Ana S. Gonzalez-Reiche,Harm van Bakel,Adolfo García-Sastre,Tim J. Anderson,Jordi B. Torrelles,Chengjin Ye,Luis Martinez-Sobrido +16 more
TL;DR: In this article, a reverse-genetics system was used to generate recombinant SARS-CoV-2 (rSARSCoV2) constructs, and the resulting recombinant viruses were characterized in vitro and in vivo.
Journal ArticleDOI
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Qian Zhang,Andrés Pizzorno,Lisa Miorin,Paul Bastard,A Gervais,Tom Le Voyer,Lucy Bizien,Jeremy Manry,Jérémie Rosain,Quentin Philippot,Kelian Goavec,Blandine Padey,Anastasija Cupic,Emilie Laurent,Kahina Saker,M. Vanker,Karita Särekannu,Tamara García-Salum,Marcela Ferrés,Nicole Le Corre,Javier Sánchez-Céspedes,María Balsera-Manzanero,Jordi Carratalà,P Retamar-Gentil,Gabriela Abelenda-Alonso,Adoración Valiente,Pierre Tiberghien,Marie Zins,Stéphanie Debette,Isabelle Meyts,Filomeen Haerynck,Riccardo Castagnoli,Luigi D. Notarangelo,Luis Ignacio Gonzalez-Granado,Nerea Domínguez-Pinilla,Evangelos Andreakos,Vasiliki Triantafyllia,Carlos Rodríguez-Gallego,Jordi Solé-Violán,José Juan Ruiz-Hernández,Felipe Rodríguez de Castro,José Ferreres,M. Luisa Briones,Joost Wauters,Lore Vanderbeke,Simon Feys,Chen Yen Kuo,Wei Li,Chen-Lung Ku,Galit Tal,Amos Etzioni,Suhair Hanna,Thomas Fournet,Jean-Sébastien Casalegno,Grégory Quéromès,Laurent Argaud,Etienne Javouhey,Manuel Rosa-Calatrava,Elisa Cordero,Teresa Aydillo,Rafael A. Medina,Kai Kisand,Anne Puel,Emmanuelle Jouanguy,Laurent Abel,Aurélie Cobat,Sophie Trouillet-Assant,Adolfo García-Sastre,Jean-Laurent Casanova +68 more
TL;DR: In an international cohort of 279 patients with hypoxemic influenza pneumonia, 13 patients were identified with autoantibodies neutralizing IFN-α and/or -ω, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine.
Posted ContentDOI
Physiology of cardiomyocyte injury in COVID-19
Mustafa M. Siddiq,Angel T Chan,Angel T Chan,Lisa Miorin,Arjun Singh Yadaw,Kristin G. Beaumont,Thomas Kehrer,Kris M. White,Anastasija Cupic,Rosa E Tolentino,Bin Hu,Alan D Stern,Iman Tavassoly,Jens Hansen,Pedro Martinez,Nicole Dubois,Christoph Schaniel,Rupa Iyengar-Kapuganti,Nina Kukar,Gennaro Giustino,Karan Sud,Sharon Nirenberg,Patricia Kovatch,Joseph Goldfarb,Lori B. Croft,Maryann McLaughlin,Edgar Argulian,Stamatios Lerakis,Jagat Narula,Adolfo Garcia-Sastre,Ravi Iyengar +30 more
TL;DR: Cell biological and physiological analyses of human cardiomyocytes differentiated from human induced pluripotent stem cells infected with SARS-CoV-2 in the presence of interleukins are integrated to investigate plausible mechanisms of cardiac disease in COVID-19 patients.