http://manuscript.elsevier.com/S0092867422006481/pdf/S0092867422006481.pdf

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.

http://www.cell.com/article/S1550413122003138/pdf

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout life, a wealth of evidence indicates deficient DNA damage repair underlies many neurological disorders, especially age‐associated neurodegenerative diseases. Recently, efforts to clarify the molecular link between DNA damage and neurodegeneration have improved our understanding of how the genomic location of DNA damage and defunct repair proteins impact neuron health. Additionally, work establishing a role for senescence in the aging and diseased brain reveals DNA damage may play a central role in neuroinflammation associated with neurodegenerative disease.

https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.202154217

Ravi K. Agarwal

Papers

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients