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Shauna H. Yuan
Researcher at University of Minnesota
Publications - 2
Citations - 75
Shauna H. Yuan is an academic researcher from University of Minnesota. The author has contributed to research in topics: Downregulation and upregulation & Frontotemporal lobar degeneration. The author has an hindex of 1, co-authored 2 publications receiving 7 citations. Previous affiliations of Shauna H. Yuan include University of California, San Diego.
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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Jerome Mertens,Joseph R. Herdy,Joseph R. Herdy,Larissa Traxler,Simon T. Schafer,Johannes C. M. Schlachetzki,Lena Böhnke,Dylan A. Reid,Hyungjun Lee,Dina Zangwill,Diana P. Fernandes,Ravi K. Agarwal,Raffaella Lucciola,Lucia Zhou-Yang,Lukas Karbacher,Frank Edenhofer,Shani Stern,Shani Stern,Steve Horvath,Apuã C. M. Paquola,Christopher K. Glass,Shauna H. Yuan,Shauna H. Yuan,Manching Ku,Attila Szücs,Lawrence S.B. Goldstein,Douglas Galasko,Fred H. Gage +27 more
TL;DR: Using direct conversion of AD patient fibroblasts into induced neurons (iNs), the authors generated an age-equivalent neuronal model and found that iNs exhibit strong neuronal transcriptome signatures characterized by downregulation of mature neuronal properties and upregulation of immature and progenitor-like signaling pathways.