S
Shani Stern
Researcher at University of Haifa
Publications - 32
Citations - 884
Shani Stern is an academic researcher from University of Haifa. The author has contributed to research in topics: Biology & Induced pluripotent stem cell. The author has an hindex of 10, co-authored 25 publications receiving 527 citations. Previous affiliations of Shani Stern include Salk Institute for Biological Studies & Weizmann Institute of Science.
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Journal ArticleDOI
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
Simon T. Schafer,Apuã C. M. Paquola,Apuã C. M. Paquola,Shani Stern,David Gosselin,Manching Ku,Manching Ku,Monique Pena,Thomas J.M. Kuret,Marvin Liyanage,Abed AlFatah Mansour,Baptiste N. Jaeger,Baptiste N. Jaeger,Maria C. Marchetto,Christopher K. Glass,Jerome Mertens,Jerome Mertens,Fred H. Gage +17 more
TL;DR: Using a dynamic time-course approach to model developmental trajectories in autism spectrum disorder, Schafer et al. identified aberrant gene network dynamics as a part of an ongoing process that is primed early in development.
Journal ArticleDOI
Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.
Shani Stern,Renata Santos,Renata Santos,Maria C. Marchetto,Ana P.D. Mendes,Guy A. Rouleau,Steven Biesmans,Q-W Wang,Jun Yao,Patrick Charnay,Anne G. Bang,Martin Alda,Fred H. Gage +12 more
TL;DR: It is suggested that the large, fast after-hyperpolarization (AHP) is a key feature of BD and a main contributor to the fast, sustained spiking abilities of BD neurons.
Journal ArticleDOI
Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.
Anindita Sarkar,Arianna Mei,Apuã C. M. Paquola,Apuã C. M. Paquola,Shani Stern,Cedric Bardy,Cedric Bardy,Jason R. Klug,Stacy Kim,Neda Neshat,Hyung J. Kim,Hyung J. Kim,Manching Ku,Maxim N. Shokhirev,David H. Adamowicz,David H. Adamowicz,Maria C. Marchetto,Roberto Jappelli,Jennifer A. Erwin,Jennifer A. Erwin,Krishnan Padmanabhan,Krishnan Padmanabhan,Matthew Shtrahman,Matthew Shtrahman,Xin Jin,Fred H. Gage +25 more
TL;DR: A comprehensive and efficient differentiation paradigm for hiPSCs that generate multiple CA3 pyramidal neuron subtypes as detected by single-cell RNA sequencing (RNA-seq) is reported, which exhibits characteristics of neuronal network maturation.
Journal ArticleDOI
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Jerome Mertens,Joseph R. Herdy,Joseph R. Herdy,Larissa Traxler,Simon T. Schafer,Johannes C. M. Schlachetzki,Lena Böhnke,Dylan A. Reid,Hyungjun Lee,Dina Zangwill,Diana P. Fernandes,Ravi K. Agarwal,Raffaella Lucciola,Lucia Zhou-Yang,Lukas Karbacher,Frank Edenhofer,Shani Stern,Shani Stern,Steve Horvath,Apuã C. M. Paquola,Christopher K. Glass,Shauna H. Yuan,Shauna H. Yuan,Manching Ku,Attila Szücs,Lawrence S.B. Goldstein,Douglas Galasko,Fred H. Gage +27 more
TL;DR: Using direct conversion of AD patient fibroblasts into induced neurons (iNs), the authors generated an age-equivalent neuronal model and found that iNs exhibit strong neuronal transcriptome signatures characterized by downregulation of mature neuronal properties and upregulation of immature and progenitor-like signaling pathways.
Journal ArticleDOI
Cooperativity, Specificity, and Evolutionary Stability of Polycomb Targeting in Drosophila
Bernd Schuettengruber,Noa Oded Elkayam,Tom Sexton,Marianne Entrevan,Shani Stern,Aubin Thomas,Eitan Yaffe,Hugues Parrinello,Amos Tanay,Giacomo Cavalli +9 more
TL;DR: Comparative epigenomics and transgenic assays are used to show that Drosophila domain organization and PRE specification are evolutionarily conserved despite significant cis-element divergence within Polycomb domains, whereas cis- element evolution is strongly correlated with transcription factor binding divergence outside ofPolycomb domains.