L
Larissa Traxler
Researcher at Salk Institute for Biological Studies
Publications - 9
Citations - 265
Larissa Traxler is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 6 publications receiving 96 citations.
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Journal ArticleDOI
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.
Yongsung Kim,Xinde Zheng,Zoya Ansari,Mark C. Bunnell,Joseph R. Herdy,Larissa Traxler,Hyungjun Lee,Apuã C. M. Paquola,Chrysanthi Blithikioti,Manching Ku,Manching Ku,Johannes C. M. Schlachetzki,Johannes C. M. Schlachetzki,Jürgen Winkler,Frank Edenhofer,Christopher K. Glass,Andres A. Paucar,Baptiste N. Jaeger,Son Pham,Leah Boyer,Benjamin C. Campbell,Tony Hunter,Jerome Mertens,Fred H. Gage +23 more
TL;DR: The data indicate that iNs are a valuable tool for studying mitochondrial aging and support a bioenergetic explanation for the high susceptibility of the brain to aging.
Journal ArticleDOI
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Jerome Mertens,Joseph R. Herdy,Joseph R. Herdy,Larissa Traxler,Simon T. Schafer,Johannes C. M. Schlachetzki,Lena Böhnke,Dylan A. Reid,Hyungjun Lee,Dina Zangwill,Diana P. Fernandes,Ravi K. Agarwal,Raffaella Lucciola,Lucia Zhou-Yang,Lukas Karbacher,Frank Edenhofer,Shani Stern,Shani Stern,Steve Horvath,Apuã C. M. Paquola,Christopher K. Glass,Shauna H. Yuan,Shauna H. Yuan,Manching Ku,Attila Szücs,Lawrence S.B. Goldstein,Douglas Galasko,Fred H. Gage +27 more
TL;DR: Using direct conversion of AD patient fibroblasts into induced neurons (iNs), the authors generated an age-equivalent neuronal model and found that iNs exhibit strong neuronal transcriptome signatures characterized by downregulation of mature neuronal properties and upregulation of immature and progenitor-like signaling pathways.
Journal ArticleDOI
Next-generation disease modeling with direct conversion: a new path to old neurons.
TL;DR: An overview of the state of the art of direct iN conversion is provided and the key epigenetic, transcriptomic, and metabolic changes that occur in converting fibroblasts are described.
Journal ArticleDOI
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease
Larissa Traxler,Joseph R. Herdy,Davide Stefanoni,Sophie Eichhorner,Silvia Pelucchi,Attila Szücs,Alice Santagostino,Yongsung Kim,Ravi Agarwal,Johannes C. M. Schlachetzki,Christopher K. Glass,Jessica Lagerwall,Douglas Galasko,Fred H. Gage,Angelo D'Alessandro,Jerome Mertens +15 more
TL;DR: In this paper , the authors identified a metabolic switch to aerobic glycolysis in Alzheimer's disease induced neurons (iNs) from AD-derived fibroblasts, which resulted in metabolic and transcriptional changes in iNs.
Journal ArticleDOI
Human neurons to model aging: A dish best served old.
TL;DR: Different cell reprogramming methods in light of age-associated neurodegenerative diseases are explored and different approaches, advances, and limitations are discussed.