R
Reem A. El-Feky
Researcher at Great Ormond Street Hospital for Children NHS Foundation Trust
Publications - 6
Citations - 341
Reem A. El-Feky is an academic researcher from Great Ormond Street Hospital for Children NHS Foundation Trust. The author has contributed to research in topics: Transplantation & Recombination-activating gene. The author has an hindex of 4, co-authored 6 publications receiving 278 citations. Previous affiliations of Reem A. El-Feky include Ain Shams University.
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Journal ArticleDOI
A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency.
Yu Nee Lee,Francesco Frugoni,Kerry Dobbs,Jolan E. Walter,Silvia Giliani,Andrew R. Gennery,Waleed Al-Herz,Elie Haddad,Françoise LeDeist,Jack H. Bleesing,Lauren A. Henderson,Sung-Yun Pai,Robert P. Nelson,Dalia H. El-Ghoneimy,Reem A. El-Feky,Shereen M. Reda,Elham Hossny,Pere Soler-Palacín,Ramsay Fuleihan,Niraj C. Patel,Michel J. Massaad,Raif S. Geha,Jennifer M. Puck,Paolo Palma,Caterina Cancrini,Karin Chen,Mauno Vihinen,Frederick W. Alt,Luigi D. Notarangelo +28 more
TL;DR: In this paper, the authors investigated the molecular basis for phenotypic diversity presented in patients with various RAG1 mutations, and demonstrated correlation between defective recombination activity of hRAG1 mutant proteins and severity of the clinical and immunologic phenotype.
Journal ArticleDOI
T-cell receptor αβ+ and CD19+ cell–depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency
Ravi M. Shah,Reem A. El-Feky,Zohreh Nademi,Waseem Qasim,Persis Amrolia,Robert Chiesa,Kanchan Rao,Giovanna Lucchini,Juliana M.F. Silva,Austen Worth,Dawn Barge,David Ryan,Jane Conn,Andrew J. Cant,Roderick Skinner,Intan Juliana Abd Hamid,Terence J. Flood,Mario Abinun,Sophie Hambleton,Andrew R. Gennery,Paul Veys,Mary Slatter +21 more
TL;DR: Evaluating the outcomes of haploidentical or mMUD HSCT after depleting GvHD‐causing T‐cell receptor (TCR) and CD3+ cells from the graft found it a practical and viable alternative for children with a range of PIDs.
A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency
Yu Nee Lee,Francesco Frugoni,Kerry Dobbs,Jolan E. Walter,Silvia Giliani,Andrew R. Gennery,Waleed Al-Herz,Elie Haddad,Françoise LeDeist,Jack H. Bleesing,Lauren A. Henderson,Sung-Yun Pai,Robert P. Nelson,Dalia H. El-Ghoneimy,Reem A. El-Feky,Shereen M. Reda,Elham Hossny,Pere Soler-Palacín,Ramsay Fuleihan,Niraj C. Patel,Michel J. Massaad,Raif S. Geha,Jennifer M. Puck,Paolo Palma,Caterina Cancrini,Karin Chen,Mauno Vihinen,Frederick W. Alt,Luigi D. Notarangelo +28 more
TL;DR: In this article, the authors investigated the molecular basis for phenotypic diversity presented in patients with various RAG1 mutations, and demonstrated correlation between defective recombination activity of hRAG1 mutant proteins and severity of the clinical and immunologic phenotype.
Journal ArticleDOI
Umbilical cord blood transplantation without in vivo T-cell depletion for children with MHC class II deficiency
Reem A. El-Feky,Juliana M. Furtado-Silva,Robert Chiesa,Kanchan Rao,Giovanna Lucchini,Persis Amrolia,Austen Worth,Bobby Gaspar,Waseem Qasim,Paul Veys +9 more
Journal ArticleDOI
Outcome of Non-hematological Autoimmunity After Hematopoietic Cell Transplantation in Children with Primary Immunodeficiency.
Su Han Lum,Su Han Lum,Reem A. El-Feky,Federica R Achini,Federica R Achini,Adriana Margarit-Soler,Bianca Cinicola,Inigo Perez-Heras,Zohreh Nademi,Zohreh Nademi,Terry Flood,Tim Cheetham,Tim Cheetham,Austen Worth,Waseem Qasim,Rakesh Amin,Kanchan Rao,Robert Chiesa,Robbert G. M. Bredius,Persis Amrolia,Mario Abinun,Sophie Hambleton,Sophie Hambleton,Paul Veys,Andrew R. Gennery,Andrew R. Gennery,Arjan C. Lankester,Mary Slatter,Mary Slatter +28 more
TL;DR: Autoimmune thyroid disorder was the most common post-HCT AD, followed by neuromuscular disorders and rheumatological manifestations, and patients with a lower CD3+ count at 6 months post-hCT had a significant higher incidence of post- HCT AD compared to disease controls.