R
Regina Hartl
Researcher at Institute of Molecular Biotechnology
Publications - 2
Citations - 2204
Regina Hartl is an academic researcher from Institute of Molecular Biotechnology. The author has contributed to research in topics: Autophagy & Oxidative stress. The author has an hindex of 2, co-authored 2 publications receiving 2007 citations. Previous affiliations of Regina Hartl include Research Institute of Molecular Pathology.
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Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: This article showed that spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.