G
Gino Heeren
Researcher at University of Salzburg
Publications - 21
Citations - 3775
Gino Heeren is an academic researcher from University of Salzburg. The author has contributed to research in topics: Saccharomyces cerevisiae & Mitochondrion. The author has an hindex of 18, co-authored 21 publications receiving 3453 citations. Previous affiliations of Gino Heeren include Paracelsus Private Medical University of Salzburg.
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Journal ArticleDOI
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: This article showed that spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Journal ArticleDOI
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
Markus Ralser,Mirjam M.C. Wamelink,Axel Kowald,Birgit Gerisch,Gino Heeren,Eduard A. Struys,Edda Klipp,Cornelis Jakobs,Michael Breitenbach,Hans Lehrach,Sylvia Krobitsch +10 more
TL;DR: The naturally occurring inactivation of GAPDH functions as a metabolic switch for rerouting the carbohydrate flux to counteract oxidative stress, and altering the homoeostasis of cytoplasmic metabolites is a fundamental mechanism for balancing the redox state of eukaryotic cells under stress conditions.
Journal ArticleDOI
Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast
Mark Rinnerthaler,Sabrina Büttner,Peter Laun,Gino Heeren,Thomas K. Felder,Harald Klinger,Martin Weinberger,Klaus Stolze,Tomas Grousl,Jiri Hasek,Oldrich Benada,Ivana Frydlova,Andrea Klocker,Birgit Simon-Nobbe,Bettina Jansko,Hannelore Breitenbach-Koller,Tobias Eisenberg,Campbell W. Gourlay,Frank Madeo,William C. Burhans,Michael Breitenbach +20 more
TL;DR: Overexpression of YNO1 causes YCA1-dependent apoptosis, whereas deletion of the gene makes cells less sensitive to apoptotic stimuli, several independent lines of evidence point to regulation of the actin cytoskeleton by reactive oxygen species (ROS) produced by Yno1p.
Journal ArticleDOI
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.
Andreas G. Chiocchetti,Jia Zhou,Huashun Zhu,Thomas Karl,Olaf Haubenreisser,Mark Rinnerthaler,Gino Heeren,Kamil Oender,Johann W. Bauer,Helmut Hintner,Michael Breitenbach,Lore Breitenbach-Koller +11 more
TL;DR: Reduction of gene dosage of RP genes belonging to both the 60S and the 40S subunit affect lifespan, possibly altering the aging process by modulation of translation.