L
Luiza Deszcz
Researcher at Austrian Academy of Sciences
Publications - 18
Citations - 2586
Luiza Deszcz is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 6, co-authored 16 publications receiving 2239 citations. Previous affiliations of Luiza Deszcz include Research Institute of Molecular Pathology & Institute of Molecular Biotechnology.
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Journal ArticleDOI
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: This article showed that spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Journal ArticleDOI
Arginine phosphorylation marks proteins for degradation by a Clp protease
Débora Broch Trentini,Marcin J. Suskiewicz,Alexander Heuck,Robert Kurzbauer,Luiza Deszcz,Karl Mechtler,Karl Mechtler,Tim Clausen +7 more
TL;DR: The data demonstrate that phosphoarginine functions as a bona fide degradation tag for the ClpC–ClpP protease, which is widely distributed across Gram-positive bacteria, is functionally analogous to the eukaryotic ubiquitin–proteasome system.
Journal ArticleDOI
The IAP family member BRUCE regulates autophagosome–lysosome fusion
Petra Ebner,Isabella Poetsch,Luiza Deszcz,Thomas Hoffmann,Johannes Zuber,Johannes Zuber,Fumiyo Ikeda +6 more
TL;DR: The authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autolysosome-lysosome fusion and is a regulator of both macroautophagy and apoptosis.
Journal ArticleDOI
Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
Tomoko Asaoka,Jorge Almagro,Christine Ehrhardt,Isabella Tsai,Alexander Schleiffer,Alexander Schleiffer,Luiza Deszcz,Sini Junttila,Leonie Ringrose,Leonie Ringrose,Karl Mechtler,Karl Mechtler,Anoop Kavirayani,Attila Gyenesei,Kay Hofmann,Peter Duchek,Katrin Rittinger,Fumiyo Ikeda +17 more
TL;DR: Drosophila CG11321 is identified, which is named Linear Ubiquitin E3 ligase (LUBEL), and it is found that it catalyzes linear ubiquitination in vitro, and Interestingly, flies with LUBEL mutations display reduced survival and climbing defects upon heat shock,which is also observed upon specific LUBel depletion in muscle.