Heide Knauer

TL;DR: This article showed that spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.

TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.

TL;DR: It is shown that the yeast homolog of EndoG (Nuc1p) can efficiently trigger apoptotic cell death when excluded from mitochondria, suggesting a pathway in which mitochondrial pore opening, nuclear import, and chromatin association are successively involved in EndOG-mediated death.

TL;DR: The mitochondrial dimeric phospholipid cardiolipin is characterized by a high degree of unsaturation of its acyl chains, which is important for its functional interaction with mitochondrial enzymes, and the Ygr110wp, which functions upstream of Taz1p, is renamed as Cld1p (cardiolip in-specific deacylase 1).

TL;DR: This work shows that the CatD ortholog of the budding yeast Saccharomyces cerevisiae (Pep4p) harbors a dual cytoprotective function, composed of a anti-apoptotic part, conferred by its proteolytic capacity, and an anti-necrotic part which resides in the protein's proteolytically inactive propeptide.