Showing papers by "Regina Menezes published in 2018"
Technical University of Denmark1, Nova Southeastern University2, French Institute for Research in Computer Science and Automation3, Pontifical Catholic University of Chile4, University of Copenhagen5, University of Minho6, John Innes Centre7, James Hutton Institute8, Chr. Hansen9, University of Lisbon10, University of Edinburgh11, Chinese Academy of Sciences12, University of Groningen13, Delft University of Technology14, Heriot-Watt University15, Centrum Wiskunde & Informatica16
TL;DR: A review article summarizes some of the key findings obtained throughout the duration of the BACterial Hosts for production of Bioactive phenolics from bERRY fruits, a 3-year project funded by the Seventh Framework Programme.
Abstract: BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.
18 citations
TL;DR: This document stores the name of the company and a description of its products and staff, as well as some details of the products and procedures used to manufacture and distribute them.
Abstract:
6 citations
TL;DR: The use of cellular-based models of neurodegenerative diseases and the benefits of their use as potent tools in the search for bioactive molecules, particularly (poly)phenols are described.
Abstract: Our society is currently experiencing increased lifespan; one of the top causes for the high incidence of neurodegenerative disorders. The lack of effective treatments delaying or blocking disease progression has encouraged the active search for novel therapies. Many evidences support the protective role of phytochemicals in the prevention of neurodegenerative diseases, particularly (poly)phenols. In this review, we described the use of cellular-based models of neurodegenerative diseases and the benefits of their use as potent tools in the search for bioactive molecules, particularly (poly)phenols. Studies to assess the biological activity of (poly)phenols involve experimentation with in vitro and in vivo systems. In vitro systems are a useful tool as a first approach to test the underlined molecular mechanisms of candidate molecules. They can provide valuable information about biological activity, which can be then used to design animal and human intervention studies.
6 citations