Isabel Rocha

TL;DR: An evolutionary programming based method to rapidly identify gene deletion strategies for optimization of a desired phenotypic objective function is reported and shows that evolutionary programming enables solving large gene knockout problems in relatively short computational time.

TL;DR: The OptFlux software is freely available, together with documentation and other resources, thus bridging the gap from research in strain optimization algorithms and the final users, thus providing a user-friendly computational tool for Metabolic Engineering applications.

TL;DR: A community effort to develop a test suite named MEMOTE (for metabolic model tests) to assess GEM quality, and advocate adoption of the latest version of the Systems Biology Markup Language level 3 flux balance constraints (SBML3FBC) package as the primary description and exchange format.

TL;DR: The features required by an integrated framework for modeling, analyzing and simulating biological processes, and several modeling formalisms that have been used in Systems Biology including Boolean networks, Bayesian networks, Petri nets, process algebras, constraint-based models, differential equations, rule- based models, interacting state machines, cellular automata, and agent-based model are described.

TL;DR: In this article, the reaction of Aspergillus oryzae b-galactosidase free and immobilized on magnetic polysiloxane-polyvinyl alcohol (mPOS-PVA) was studied.