T
Tobias B. Dansen
Researcher at Utrecht University
Publications - 57
Citations - 4224
Tobias B. Dansen is an academic researcher from Utrecht University. The author has contributed to research in topics: Peroxisome & Transcription factor. The author has an hindex of 28, co-authored 53 publications receiving 3710 citations. Previous affiliations of Tobias B. Dansen include University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Geert J. P. L. Kops,Tobias B. Dansen,Paulien E. Polderman,Ingrid Saarloos,Karel W. A. Wirtz,Paul J. Coffer,Ting-T. Huang,Johannes L. Bos,René H. Medema,Boudewijn M.T. Burgering +9 more
TL;DR: It is shown that the PKB-regulated Forkhead transcription factor FOXO3a (also known as FKHR-L1) protects quiescent cells from oxidative stress by directly increasing their quantities of manganese superoxide dismutase messenger RNA and protein.
Journal ArticleDOI
Unravelling the tumor-suppressive functions of FOXO proteins
TL;DR: Recent advances in the understanding of the roles of FOXO family members in tumor suppression are discussed.
Journal ArticleDOI
Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy
Kristan E. van der Vos,Pernilla Eliasson,Tassula Proikas-Cezanne,Stephin J. Vervoort,Stephin J. Vervoort,Ruben van Boxtel,Marrit Putker,Iris J. van Zutphen,Mario Mauthe,Sebastian Zellmer,Cornelieke Pals,Liesbeth P. Verhagen,Marian J. A. Groot Koerkamp,A. Koen Braat,A. Koen Braat,Tobias B. Dansen,Frank C. P. Holstege,Rolf Gebhardt,Boudewijn M.T. Burgering,Paul J. Coffer,Paul J. Coffer +20 more
TL;DR: A growth-factor-responsive network that can directly modulate autophagy through the regulation of glutamine metabolism is revealed, suggesting that the induction ofautophagy by FOXO3-mediated glutamine synthetase expression is important for cellular survival.
Journal ArticleDOI
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity
Tobias B. Dansen,Lydia M.M. Smits,Miranda van Triest,Peter L.J. de Keizer,Dik van Leenen,Marian J. A. Groot Koerkamp,Anna A. Szypowska,Amanda Meppelink,Arjan B. Brenkman,Junji Yodoi,Frank C. P. Holstege,Boudewijn M.T. Burgering +11 more
TL;DR: It is shown that reactive oxygen species induce the formation of cysteine-thiol disulfide-dependent complexes of FoxO and the p300/CBP acetyltransferase, and that modulation of Fox O biological activity by p300 /CBP-mediated acetylation is fully dependent on theformation of this redox-dependent complex.
Journal ArticleDOI
Redox-dependent control of FOXO/DAF-16 by transportin-1
Marrit Putker,Tobias Madl,Harmjan R. Vos,Hesther de Ruiter,Marieke Visscher,Maaike C. W. van den Berg,Mohammed Kaplan,Hendrik C. Korswagen,Rolf Boelens,Michiel Vermeulen,Boudewijn M.T. Burgering,Tobias B. Dansen +11 more
TL;DR: It is shown that disulfide formation with transportin-1 is required for nuclear localization and the activation of FOXO4/DAF-16 induced by ROS, but not by the loss of insulin signaling, and this molecular mechanism for nuclear shuttling is conserved in C. elegans.