R
René L. Warren
Researcher at BC Cancer Agency
Publications - 121
Citations - 10250
René L. Warren is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Sequence assembly & Genome. The author has an hindex of 35, co-authored 98 publications receiving 8639 citations. Previous affiliations of René L. Warren include BC Cancer Research Centre & McGill University.
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Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Mauro Castellarin,René L. Warren,J. Douglas Freeman,Lisa Dreolini,Martin Krzywinski,Jaclyn Strauss,Rebecca O Barnes,Peter H. Watson,Emma Allen-Vercoe,Richard A. Moore,Robert A. Holt +10 more
TL;DR: Overabundance of Fusobacterium sequences in tumor versus matched normal control tissue is verified by quantitative PCR analysis from a total of 99 subjects, and a positive association with lymph node metastasis is observed.
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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
Sohrab P. Shah,Ryan D. Morin,Jaswinder Khattra,Leah M Prentice,Trevor J. Pugh,Angela Burleigh,Allen Delaney,Karen A. Gelmon,Ryan Guliany,Janine Senz,Christian Steidl,Robert A. Holt,Steven J.M. Jones,Mark G. F. Sun,Gillian Leung,Richard A. Moore,Tesa M. Severson,Greg Taylor,Andrew E. Teschendorff,Kane Tse,Gulisa Turashvili,Richard Varhol,René L. Warren,Peter H. Watson,Yongjun Zhao,Carlos Caldas,David G. Huntsman,Martin Hirst,Marco A. Marra,Samuel Aparicio +29 more
TL;DR: The data show that single nucleotide mutational heterogeneity can be a property of low or intermediate grade primary breast cancers and that significant evolution can occur with disease progression, and two new RNA-editing events that recode the amino acid sequence of SRP9 and COG3 are revealed.
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The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
TL;DR: The tissue‐restricted GATA‐4 transcription factor and Nkx2‐5 homeodomain protein are two early markers of precardiac cells and the GATA/Nkx partnership may represent a paradigm for transcription factor interaction during organogenesis.
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The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse
Michael P. McLeod,René L. Warren,William W. L. Hsiao,Naoto Araki,Matthew Myhre,Clinton Fernandes,Daisuke Miyazawa,Wendy Wong,Anita L. Lillquist,Dennis Wang,Manisha Dosanjh,Hirofumi Hara,Anca Petrescu,Ryan D. Morin,George S. Yang,Jeff M. Stott,Jacqueline E. Schein,Heesun Shin,Duane E. Smailus,Asim Siddiqui,Marco A. Marra,Steven J.M. Jones,Robert A. Holt,Fiona S. L. Brinkman,Keisuke Miyauchi,Masao Fukuda,Julian Davies,William W. Mohn,Lindsay D. Eltis +28 more
TL;DR: Overall, RHA1 appears to have evolved to simultaneously catabolize a diverse range of plant-derived compounds in an O2-rich environment and is established as an important model for studying actinomycete physiology.
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Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
Scott D. Brown,Scott D. Brown,René L. Warren,Ewan A. Gibb,Ewan A. Gibb,Spencer D. Martin,Spencer D. Martin,John J. Spinelli,John J. Spinelli,Brad H. Nelson,Brad H. Nelson,Brad H. Nelson,Robert A. Holt,Robert A. Holt,Robert A. Holt +14 more
TL;DR: For 515 patients from six tumor sites, RNA-seq data from The Cancer Genome Atlas was used to identify mutations that were predicted to be immunogenic in that they yielded mutational epitopes presented by the MHC proteins encoded by each patient's autologous HLA-A alleles that were associated with increased patient survival.