Scott D. Brown

TL;DR: An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.

TL;DR: For 515 patients from six tumor sites, RNA-seq data from The Cancer Genome Atlas was used to identify mutations that were predicted to be immunogenic in that they yielded mutational epitopes presented by the MHC proteins encoded by each patient's autologous HLA-A alleles that were associated with increased patient survival.

TL;DR: It is concluded that within-patient spatial immune microenvironment variation shapes intraperitoneal malignant spread, provoking new evolutionary perspectives on HGSC clonal dispersion.

TL;DR: The findings highlight the limitations of applying neoantigen-targeted vaccines to tumor types with intermediate/low mutation burdens and highlight the need to understand more fully the rationale behind the selection of these vaccines.

TL;DR: The POG570 cohort is described, a comprehensive whole-genome, transcriptome and clinical dataset, amenable for exploration of the impacts of therapies on genomic landscapes, and mutation burden and immune signatures corresponded with overall survival and response to immunotherapy.