Rene Williams

TL;DR: Clinical and laboratory findings in eight British adult patients who presented with symptoms typical of CAPS other than an onset in mid-late adulthood suggest acquired NLRP3 mutations may not be an uncommon cause of the syndrome and should be sought in all patients with late-onset symptoms otherwise compatible with CAPS.

TL;DR: This series substantially increases the published experience of IL-1 blockade and reproduction including the first data on canakinumab and on paternal exposure to these agents.

TL;DR: The findings do not support a role for somatic NLRP3 mosaicism in disease pathogenesis; although elevated levels of ASC, IL-6, and IL-18 in patients' serum, and the response to anakinra, suggest that Schnitzler syndrome is associated with upregulated inflammasome activation.

TL;DR: Unusually severe adverse reactions to pneumococcal vaccination in each of 7 consecutive patients with cryopyrin‐associated periodic syndromes (CAPS) are described.

TL;DR: The outcomes of 20 IL-1 inhibitor exposed pregnancies in 18 women from 7 countries and paternal exposure to anakinra or canakinumab at conception are reported.