T
Theodore R. Sana
Researcher at Merck & Co.
Publications - 40
Citations - 1800
Theodore R. Sana is an academic researcher from Merck & Co.. The author has contributed to research in topics: Nucleic acid & Polyclonal antibodies. The author has an hindex of 18, co-authored 38 publications receiving 1683 citations. Previous affiliations of Theodore R. Sana include Agilent Technologies & Schering-Plough.
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Journal ArticleDOI
Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2
Reno Debets,Jackie C. Timans,Bernhard Homey,Sandra Zurawski,Theodore R. Sana,Sylvia Lo,Janet Wagner,Gina Edwards,Teresa Clifford,Satish Menon,J. Fernando Bazan,Robert A. Kastelein +11 more
TL;DR: IL-1δ and ε may constitute an independent signaling system, analogous to IL-1αβ/receptor agonist and Il-1R1, that is present in epithelial barriers of the authors' body and takes part in local inflammatory responses.
Journal ArticleDOI
Rapid quantitative profiling of complex microbial populations
Chana Palmer,Elisabeth M. Bik,Michael B. Eisen,Paul B. Eckburg,Theodore R. Sana,Paul K. Wolber,David A. Relman,Patrick O. Brown +7 more
TL;DR: A DNA oligonucleotide microarray composed of SSU ribosomal DNA probes selected to provide quantitative information on the taxonomic composition of diverse microbial populations can be used to explore and systematically characterize complex microbial communities, such as those found within the human body.
Journal ArticleDOI
Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression
Nagireddy Putluri,Ali Shojaie,Ali Shojaie,Vihas T. Vasu,Vihas T. Vasu,Shaiju K. Vareed,Srilatha Nalluri,Vasanta Putluri,Gagan Thangjam,Katrin Panzitt,Christopher Tallman,Charles Butler,Theodore R. Sana,Steven M. Fischer,Gabriel Sica,Daniel J. Brat,Huidong Shi,Huidong Shi,Ganesh S. Palapattu,Yair Lotan,Alon Z. Weizer,Martha K. Terris,Martha K. Terris,Shahrokh F. Shariat,George Michailidis,Arun Sreekumar,Arun Sreekumar +26 more
TL;DR: The metabolomic signature described offers potential as a urinary biomarker for early detection and staging of bladder cancer, highlighting the utility of evaluating metabolomic profiles of cancer to gain insights into bioprocesses perturbed during tumor development and progression.
Journal ArticleDOI
Metabolomic and transcriptomic analysis of the rice response to the bacterial blight pathogen Xanthomonas oryzae pv. oryzae
Theodore R. Sana,Steve Fischer,Gert Wohlgemuth,Anjali Katrekar,Ki-Hong Jung,Pamela C. Ronald,Oliver Fiehn +6 more
TL;DR: Significant transcriptional induction of several pathogenesis related genes in Xa21 challenged strains, as well as differential changes to GAD, PAL, ICL1 and Glutathione-S-transferase transcripts indicated limited correlation with metabolite changes under single time point global profiling conditions.
Journal Article
Molecular formula and METLIN Personal Metabolite Database matching applied to the identification of compounds generated by LC/TOF-MS.
TL;DR: The results suggest that the METLIN Personal Metabolite database and MFG software offer a robust strategy for confirming the formula of database matches from the accurate mass spectral data.