Renren Wen

TL;DR: It is shown that STAT5 negatively regulates Tfh development by up-regulating Blimp-1 and thus controls the humoral immunity and B cell tolerance and may help to find new ways to treat antibody-mediated autoimmune diseases.

TL;DR: It is shown that absence of Bcl10 impeded conversion from transitional type 2 to mature follicular B cells and caused substantial decreases in marginal zone and B1 B cells, and both B cl10-deficient follicular and marginal zone B cells failed to proliferate normally.

TL;DR: It is demonstrated that down-regulation of the tyrosine-phosphorylated Stat5A was via deph phosphorylation, and it is concluded that Shp-2 is aStat5A phosphatase, which down-regulates the active Stat 5A in vivo.

TL;DR: Karyotypic analyses of MEFs and lymphomas from DMP1-null animals revealed pseudodiploid chromosome numbers, consistent with the retention of wild-type p53, which suggest that ARF function is compromised, but not eliminated, in animals lacking functional D MP1.

TL;DR: It is demonstrated that the deficiency of Bcl10 resulted in the defect in NF-κB activation induced by either expressing the constitutively active mutant of G protein or stimulation of cells with lysophosphatidic acid or endothelin-1, which activate their GPCR.