Rhim Ryoo

TL;DR: Findings provide experimental evidence suggesting the potential anti-cancer effects of trichothecene sesquiterpenes from a poisonous mushroom.

TL;DR: The 46.1 Mb draft genome of L. edodes is presented, comprising 13,028 predicted gene models, andGene annotation provides key information about various signaling pathways and secondary metabolites that should help establish the molecular genetic markers for MAS/MAB and increase the understanding of the genome structure and function.

TL;DR: The data demonstrate that the sclerotium of P. cocos and its four bioactive constituents exert cytotoxicity against human lung adenocarcinoma cells, regardless of their p53 status, by inducing apoptosis associated with mitochondrial perturbation, and propose the potential to employ P. coconutos in the treatment of lung cancer.

TL;DR: Three new macrocyclic trichothecenes (1-3) and five known related compounds (4-8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly poisonous mushroom, and cytotoxicity against four human breast cancer cell lines was evaluated.

TL;DR: Findings demonstrate that the EtOH extract of P. cocos sclerotia is worth consideration as a new potential source of bioactive compounds effective in the treatment of osteoporosis in the elderly, since the extract contains sterols that inhibit adipogenic differentiation as well as diterpenes that promote osteogenic differentiation from MSCs.