Kwan-Hyuck Baek

TL;DR: It is shown that testicular endothelial cells (TECs) are part of the SSC niche producing glial cell line-derived neurotrophic factor (GDNF) and other factors to support human and mouse SSCs in long-term culture.

TL;DR: Bioactivity-guided fractionation of the KRG extract revealed that its ethyl acetate–soluble fraction exerts significant cytotoxic activity against all human lung cancer cell lines tested by inducing apoptosis, providing experimental evidence for a novel biological activity of ginsenoside Rg3 againsthuman lung cancer cells.

TL;DR: Findings provide the first experimental evidence for potential use of B. platyphylla var.

TL;DR: The data demonstrate that the sclerotium of P. cocos and its four bioactive constituents exert cytotoxicity against human lung adenocarcinoma cells, regardless of their p53 status, by inducing apoptosis associated with mitochondrial perturbation, and propose the potential to employ P. coconutos in the treatment of lung cancer.

TL;DR: These findings provide experimental evidence supporting the potential application of I. obliquus in lung cancer treatment and reveal the molecular basis underlying its cytotoxic activity against human lung cancer cells.