Hyun-Soo Roh

TL;DR: Bioactivity-guided fractionation of the KRG extract revealed that its ethyl acetate–soluble fraction exerts significant cytotoxic activity against all human lung cancer cell lines tested by inducing apoptosis, providing experimental evidence for a novel biological activity of ginsenoside Rg3 againsthuman lung cancer cells.

TL;DR: The data demonstrate that the sclerotium of P. cocos and its four bioactive constituents exert cytotoxicity against human lung adenocarcinoma cells, regardless of their p53 status, by inducing apoptosis associated with mitochondrial perturbation, and propose the potential to employ P. coconutos in the treatment of lung cancer.

TL;DR: These findings provide experimental evidence supporting the potential application of I. obliquus in lung cancer treatment and reveal the molecular basis underlying its cytotoxic activity against human lung cancer cells.

TL;DR: Among the eight isolated compounds tested, compounds 1, 3, and 5 exhibited the most potent cytotoxicity to human lung cancer cell lines, with IC50 values ranging from 156.9 to 278 M; this activity was mediated by induction of apoptosis.

TL;DR: Findings suggest a novel biological application of P. koraiensis pinecones in combatting human lung cancer, and further identify the major compounds that could contribute to this anticancer activity.