R
Ricardo A. M. Serafim
Researcher at University of Tübingen
Publications - 6
Citations - 29
Ricardo A. M. Serafim is an academic researcher from University of Tübingen. The author has contributed to research in topics: Kinase & Chemistry. The author has an hindex of 1, co-authored 6 publications receiving 5 citations. Previous affiliations of Ricardo A. M. Serafim include State University of Campinas & Structural Genomics Consortium.
Papers
More filters
Journal ArticleDOI
Chemical Probes for Understudied Kinases: Challenges and Opportunities.
Ricardo A. M. Serafim,Jonathan M. Elkins,William J. Zuercher,Stefan Laufer,Matthias Gehringer +4 more
TL;DR: In this paper, the authors highlight recent case studies illustrating the development of high-quality chemical probes for less-studied kinases and their application in target validation and discuss the associated challenges and opportunities.
Journal ArticleDOI
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
Ricardo A. M. Serafim,Ricardo A. M. Serafim,Fernando H. de Souza Gama,Luiz A Dutra,Luiz A Dutra,Caio V. dos Reis,Caio V. dos Reis,Stanley Nunes Siqueira Vasconcelos,Stanley Nunes Siqueira Vasconcelos,A.S. Santiago,A.S. Santiago,Jessica Takarada,Jessica Takarada,Fulvia Di Pillo,Hatylas Azevedo,Alessandra Mascarello,Jonathan M. Elkins,Katlin B. Massirer,Katlin B. Massirer,Opher Gileadi,Cristiano Ruch Werneck Guimarães,Rafael M. Couñago,Rafael M. Couñago +22 more
TL;DR: The discovery and elaboration of an aminopyridine scaffold as a basis for VRK1 and VRK2 inhibitors is reported, expected to serve as a starting point for the design of more specific and potent inhibitors against each of the two VRKs.
Journal ArticleDOI
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Ricardo A. M. Serafim,Ricardo A. M. Serafim,F.J. Sorrell,Benedict-Tilman Berger,Benedict-Tilman Berger,Ross J. Collins,Stanley Nunes Siqueira Vasconcelos,Stanley Nunes Siqueira Vasconcelos,Katlin B. Massirer,Katlin B. Massirer,Stefan Knapp,Stefan Knapp,Jim Bennett,Oleg Fedorov,Hitesh Patel,William J. Zuercher,Jonathan M. Elkins,Jonathan M. Elkins +17 more
TL;DR: In this paper, a series of 3-anilino-4-arylmaleimides were identified as dual inhibitors of SLK and STK10 with good kinome-wide selectivity.
Journal ArticleDOI
Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2).
Stefan Gerstenecker,Lisa Haarer,Martin Schröder,Mark Kudolo,Martin P. Schwalm,Valentin Wydra,Ricardo A. M. Serafim,Apirat Chaikuad,Stefan Knapp,Stefan Laufer,Matthias Gehringer +10 more
TL;DR: In this article, the authors designed the first potent and highly isoform-specific S6K2 inhibitor from a known S 6K1-selective inhibitor, which was merged with a covalent inhibitor engaging a cysteine located in the hinge region in the fibroblast growth factor receptor kinase (FGFR) 4 via a nucleophilic aromatic substitution (SNAr) reaction.
Posted ContentDOI
Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)
Stefan Gerstenecker,Lisa Haarer,Martin Schröder,Mark Kudolo,Martin P. Schwalm,Valentin Wydra,Ricardo A. M. Serafim,Apirat Chaikuad,Stefan Knapp,Stefan Laufer,Matthias Gehringer +10 more
TL;DR: The title compound shows high selectivity over kinases with an equivalently positioned cysteine as well as in a larger kinase panel and good stability towards glutathione indicated a non-promiscuous reactivity pattern.