K
Katlin B. Massirer
Researcher at State University of Campinas
Publications - 46
Citations - 2638
Katlin B. Massirer is an academic researcher from State University of Campinas. The author has contributed to research in topics: Kinase & Medicine. The author has an hindex of 13, co-authored 38 publications receiving 2336 citations. Previous affiliations of Katlin B. Massirer include Structural Genomics Consortium & University of São Paulo.
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Journal ArticleDOI
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation.
Shveta Bagga,John R. Bracht,Shaun Hunter,Katlin B. Massirer,Janette Holtz,Rachel Eachus,Amy E. Pasquinelli +6 more
TL;DR: It is revealed that mRNAs containing partial miRNA complementary sites can be targeted for degradation in vivo, raising the possibility that regulation at the level of mRNA stability may be more common than previously appreciated for the miRNA pathway.
Journal ArticleDOI
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
Michael T. Lovci,Dana Ghanem,Henry Marr,Justin K. Arnold,Sherry Gee,Marilyn Parra,Tiffany Y. Liang,Thomas J. Stark,Lauren T Gehman,Shawn Hoon,Shawn Hoon,Katlin B. Massirer,Gabriel A. Pratt,Douglas L. Black,Joe W. Gray,John G. Conboy,Gene W. Yeo +16 more
TL;DR: It is shown here that binding in distal intronic regions by Rbfox splicing factors important in development is extensive and is an active mode of splicing regulation.
Journal ArticleDOI
LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance
Melissa L. Wilbert,Stephanie C. Huelga,Katannya Kapeli,Thomas J. Stark,Tiffany Y. Liang,Stella X. Chen,Bernice Y. Yan,Jason L. Nathanson,Kasey R. Hutt,Michael T. Lovci,Hilal Kazan,Anthony Q. Vu,Katlin B. Massirer,Katlin B. Massirer,Quaid Morris,Shawn Hoon,Gene W. Yeo,Gene W. Yeo +17 more
TL;DR: Findings identify important regulatory functions of LIN28 via direct mRNA interactions through crosslinking and immunoprecipitation coupled with high-throughput sequencing in human embryonic stem cells and somatic cells expressing exogenous LIN28.
Journal ArticleDOI
LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans.
Priscilla M. Van Wynsberghe,Zoya S. Kai,Katlin B. Massirer,Victoria H Burton,Gene W. Yeo,Amy E. Pasquinelli +5 more
TL;DR: It is concluded that co-transcriptional interaction of LIN-28 with let-7 primary transcripts blocks Drosha processing and, thus, precocious expression of matureLet-7 during early development.
Journal ArticleDOI
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
Patty Sachamitr,Patty Sachamitr,Jolene Caifeng Ho,Felipe Ciamponi,Felipe Ciamponi,Wail Ba-alawi,Wail Ba-alawi,Fiona J. Coutinho,Paul Guilhamon,Paul Guilhamon,Michelle Kushida,Florence M.G. Cavalli,Lilian Lee,Naghmeh Rastegar,Victoria Vu,Victoria Vu,María Sánchez-Osuna,Jasmin Coulombe-Huntington,Evgeny Kanshin,Heather Whetstone,Mathieu Durand,Philippe Thibault,Kirsten Hart,Kirsten Hart,Maria M. Mangos,Joseph Veyhl,Wenjun Chen,Nhat Tran,Bang-Chi Duong,Ahmed Aman,Xinghui Che,Xiaoyang Lan,Owen Whitley,Olga Zaslaver,Dalia Barsyte-Lovejoy,Dalia Barsyte-Lovejoy,Laura M. Richards,Laura M. Richards,Ian Restall,Amy Caudy,Amy Caudy,Hannes L. Röst,Zahid Quyoom Bonday,Mark Bernstein,Mark Bernstein,Sunit Das,Sunit Das,Michael D. Cusimano,Julian Spears,Gary D. Bader,Trevor J. Pugh,Trevor J. Pugh,Trevor J. Pugh,Mike Tyers,Mathieu Lupien,Mathieu Lupien,Mathieu Lupien,Benjamin Haibe-Kains,H. Artee Luchman,Samuel Weiss,Katlin B. Massirer,Katlin B. Massirer,Panagiotis Prinos,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Peter B. Dirks +66 more
TL;DR: In this paper, orthogonal-acting inhibitors of protein arginine methyltransferase 5 (PRMT5) have been shown to cause widespread disruption of splicing across the transcriptome.