Paolo Guarnieri

TL;DR: The authors' data provide clues as to how neurons and astrocytes differ in their ability to dynamically regulate glycolytic flux and lactate generation attributable to unique splicing of PKM2, the gene encoding the glycoleytic enzyme pyruvate kinase.

TL;DR: SiRNA silencing of 13 miR-mediated PTEN regulators was sufficient to downregulate PTEN in a 3'UTR-dependent manner and to increase tumor cell growth rates, providing a mechanistic, experimentally validated rationale for the loss of PTEN expression in a large number of glioma samples with an intact PTEN locus.

TL;DR: It is suggested that Parp1 and Tet2 contribute to an epigenetic program that directs subsequent transcriptional induction at pluripotency loci during somatic cell reprogramming.

TL;DR: Insight is offered into the relationship between adult glial progenitors and Proneural GBM, and molecular alterations that lead to more aggressive tumor growth are identified.

TL;DR: It is concluded that motor neuron autophagy is required to maintain neuromuscular innervation early in disease but eventually acts in a non–cell-autonomous manner to promote disease progression.