Richard G. Melvin

TL;DR: The Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum, suggesting that longevity can be extended in ad Libitum-fed animals by manipulating the ratio of macronutrients.

TL;DR: Recent discoveries spanning the Metazoa suggest that sirtuins, the mammalian circadian clock, fibroblast growth factor 21 (FGF21) and lipids are involved in torpor induction, and this review discusses how these recent discoveries form a new hypothesis linking changes in the physical environment withChanges in the expression of genes that regulate torpor initiation.

TL;DR: It is concluded that mitochondrial DNA mutations can be important in determining aspects of organism life history, and the potential for quaternary structure modelling to predict the functional consequence of specific naturally occurring mutations is reviewed.

TL;DR: In this paper, sequence data from the three mtDNA encoded cytochrome c oxidase genes show that there are 76 synonymous and two nonsynonymous fixed differences among flies harboring siII compared with siIII mtDNA.

TL;DR: The potential for tetracycline to influence mitochondrial efficiency and mitochondrial DNA density two generations after treatment in Drosophila simulans is investigated and it is observed that antibiotic treatment resulted in a decline in inorganic phosphate incorporated into ATP per mole of oxygen consumed.