Samantha M. Solon-Biet

TL;DR: The Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum, suggesting that longevity can be extended in ad Libitum-fed animals by manipulating the ratio of macronutrients.

TL;DR: It is shown that, as in invertebrates, the balance of macronutrients has marked and largely opposing effects on reproductive and longevity outcomes.

TL;DR: It is shown that when dietary BCAAs are varied against a fixed, isocaloric macronutrient background, long-term exposure to high BCAA diets leads to hyperphagia, obesity and reduced lifespan, which reduces lifespan as a consequence of obesity.

TL;DR: Geometric Framework studies on insects and mice have revealed that diets low in protein and high in carbohydrates generate longest lifespans in ad libitum-fed animals while low total energy intake (caloric restriction by dietary dilution) has minimal effect.

TL;DR: The Geometric Framework, a nutritional modeling platform, is used to help reconcile apparently conflicting findings in mice confined to one of 25 diets that varied in protein, carbohydrate, and fat content, and show that FGF21 was elevated under low protein intakes and maximally when low protein was coupled with high carbohydrate intakes.