The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
Samantha M. Solon-Biet,Aisling C. McMahon,J. William O. Ballard,Kari Ruohonen,Lindsay E. Wu,Victoria C. Cogger,Alessandra Warren,Xin Huang,Nicolas Pichaud,Richard G. Melvin,Rahul Gokarn,Mamdouh Khalil,Nigel Turner,Gregory J. Cooney,David A. Sinclair,David A. Sinclair,David Raubenheimer,David G. Le Couteur,Stephen J. Simpson +18 more
TLDR
The Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum, suggesting that longevity can be extended in ad Libitum-fed animals by manipulating the ratio of macronutrients.About:
This article is published in Cell Metabolism.The article was published on 2014-03-04 and is currently open access. It has received 732 citations till now. The article focuses on the topics: Calorie restriction & Longevity.read more
Citations
More filters
Journal ArticleDOI
Multi-omics approaches to disease.
TL;DR: This review provides an overview of omics technologies and methods for their integration across multiple omics layers and offers the opportunity to understand the flow of information that underlies disease.
Journal ArticleDOI
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Luigi Fontana,Linda Partridge +1 more
TL;DR: Findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake.
Journal ArticleDOI
Facing up to the global challenges of ageing.
TL;DR: Interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health in humans.
Journal ArticleDOI
Metabolic Control of Longevity
TL;DR: The introduction of strategies that promote metabolic fitness may extend healthspan in humans as several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock" that controls aging.
Journal ArticleDOI
Interventions to Slow Aging in Humans: Are We Ready?
Valter D. Longo,Adam Antebi,Andrzej Bartke,Nir Barzilai,Holly M. Brown-Borg,Calogero Caruso,Tyler J. Curiel,Rafael de Cabo,Claudio Franceschi,David Gems,Donald K. Ingram,Thomas E. Johnson,Brian K. Kennedy,Cynthia Kenyon,Samuel Klein,John J. Kopchick,G Lepperdinger,Frank Madeo,Mario G. Mirisola,James R. Mitchell,Giuseppe Passarino,Karl Lenhard Rudolph,John M. Sedivy,Gerald S. Shadel,David A. Sinclair,David A. Sinclair,Stephen R. Spindler,Yousin Suh,Jan Vijg,Manlio Vinciguerra,Luigi Fontana,Luigi Fontana +31 more
TL;DR: There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.
References
More filters
Book
Data Analysis Using Regression and Multilevel/Hierarchical Models
Andrew Gelman,Yu-Sung Su +1 more
TL;DR: Data Analysis Using Regression and Multilevel/Hierarchical Models is a comprehensive manual for the applied researcher who wants to perform data analysis using linear and nonlinear regression and multilevel models.
Book
Generalized Additive Models: An Introduction with R, Second Edition
TL;DR: In this article, a simple linear model is proposed to describe the geometry of linear models, and a general linear model specification in R is presented. But the theory of linear model theory is not discussed.
Book
Modeling Survival Data: Extending the Cox Model
TL;DR: A Cox Model-based approach was used to estimate the Survival and Hazard Functions and the results confirmed the need for further investigation into the role of natural disasters in shaping survival rates.
Journal ArticleDOI
Generalized Additive Models: An Introduction With R
TL;DR: Robinson, R. (2007). Generalized Additive Models: An Introduction With R.(2007).
Journal ArticleDOI
Effects of the obese gene product on body weight regulation in ob/ob mice
Mary Ann Pelleymounter,Mary Jane Cullen,Mary Beth Baker,Randy Ira Hecht,Dwight Winters,Thomas C. Boone,Frank H. Collins +6 more
TL;DR: The data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.
Related Papers (5)
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
Morgan E. Levine,Jorge Suarez,Sebastian Brandhorst,Priya Balasubramanian,Chia-Wei Cheng,Federica Madia,Luigi Fontana,Luigi Fontana,Mario G. Mirisola,Mario G. Mirisola,Jaime Guevara-Aguirre,Junxiang Wan,Giuseppe Passarino,Brian K. Kennedy,Min Wei,Pinchas Cohen,Eileen M. Crimmins,Valter D. Longo +17 more