A
Aisling C. McMahon
Researcher at University of Sydney
Publications - 39
Citations - 2352
Aisling C. McMahon is an academic researcher from University of Sydney. The author has contributed to research in topics: Oxidative stress & Reperfusion injury. The author has an hindex of 18, co-authored 39 publications receiving 1908 citations. Previous affiliations of Aisling C. McMahon include Concord Repatriation General Hospital & Concord Hospital.
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Journal ArticleDOI
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
Samantha M. Solon-Biet,Aisling C. McMahon,J. William O. Ballard,Kari Ruohonen,Lindsay E. Wu,Victoria C. Cogger,Alessandra Warren,Xin Huang,Nicolas Pichaud,Richard G. Melvin,Rahul Gokarn,Mamdouh Khalil,Nigel Turner,Gregory J. Cooney,David A. Sinclair,David A. Sinclair,David Raubenheimer,David G. Le Couteur,Stephen J. Simpson +18 more
TL;DR: The Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum, suggesting that longevity can be extended in ad Libitum-fed animals by manipulating the ratio of macronutrients.
Journal ArticleDOI
Characterization of Reproductive, Metabolic, and Endocrine Features of Polycystic Ovary Syndrome in Female Hyperandrogenic Mouse Models
Aimee S L Caldwell,Linda J. Middleton,Mark Jimenez,Reena Desai,Aisling C. McMahon,Charles M. Allan,David J. Handelsman,Kirsty A Walters +7 more
TL;DR: The findings reveal that long-term DHT treatment replicated a breadth of ovarian, endocrine, and metabolic features of human PCOS and provides the best mouse model for experimental studies of PCOS pathogenesis.
Journal ArticleDOI
Macronutrient balance, reproductive function, and lifespan in aging mice
Samantha M. Solon-Biet,Kirsty A Walters,Ulla Simanainen,Aisling C. McMahon,Kari Ruohonen,J. W. O. Ballard,David Raubenheimer,David J. Handelsman,David G. Le Couteur,Stephen J. Simpson +9 more
TL;DR: It is shown that, as in invertebrates, the balance of macronutrients has marked and largely opposing effects on reproductive and longevity outcomes.
Journal ArticleDOI
Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework
Samantha M. Solon-Biet,Victoria C. Cogger,Tamara Pulpitel,Marika Heblinski,Devin Wahl,Aisling C. McMahon,Alessandra Warren,Jessica Durrant-Whyte,Kirsty A Walters,Kirsty A Walters,James R. Krycer,Fleur Ponton,Fleur Ponton,Rahul Gokarn,Jibran A Wali,Kari Ruohonen,Arthur D. Conigrave,David E. James,David Raubenheimer,Christopher D. Morrison,David G. Le Couteur,Stephen J. Simpson +21 more
TL;DR: The Geometric Framework, a nutritional modeling platform, is used to help reconcile apparently conflicting findings in mice confined to one of 25 diets that varied in protein, carbohydrate, and fat content, and show that FGF21 was elevated under low protein intakes and maximally when low protein was coupled with high carbohydrate intakes.
Journal ArticleDOI
Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice
Samantha M. Solon-Biet,Sarah J. Mitchell,Sean C. P. Coogan,Victoria C. Cogger,Rahul Gokarn,Aisling C. McMahon,David Raubenheimer,Rafael de Cabo,Stephen J. Simpson,David G. Le Couteur +9 more
TL;DR: It is shown that LPHC diets under ad-libitum-fed conditions generate the metabolic benefits of CR without a 40% reduction in total caloric intake.