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Richard L. Gardner
Researcher at University of Oxford
Publications - 66
Citations - 8102
Richard L. Gardner is an academic researcher from University of Oxford. The author has contributed to research in topics: Blastocyst & Stem cell. The author has an hindex of 39, co-authored 66 publications receiving 7804 citations. Previous affiliations of Richard L. Gardner include National Foundation for Cancer Research & University of Cambridge.
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Journal ArticleDOI
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Paul J. Tesar,Josh G. Chenoweth,F. A. Brook,Timothy J. Davies,Edward P. Evans,David L. Mack,Richard L. Gardner,Ronald D.G. McKay +7 more
TL;DR: It is shown that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the embryo proper, and interrogated to understand how pluripotent cells generate distinct fates during early development.
Journal ArticleDOI
The origin and efficient derivation of embryonic stem cells in the mouse
F. A. Brook,Richard L. Gardner +1 more
TL;DR: By explanting tissues isolated microsurgically from implanting strain 129 mouse blastocysts individually on STO feeder cells, it is established that embryonic stem (ES) cells originate from the epiblast (primitive ectoderm).
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Fate of teratocarcinoma cells injected into early mouse embryos
TL;DR: It is shown here that embryonal carcinoma cells can participate in normal embryogenesis, thus providing further evidence for the validity of the use of these cultures as a model of normal embryonic development.
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Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts.
Tilo Kunath,Tilo Kunath,Danielle Arnaud,Gary D. Uy,Ikuhiro Okamoto,Corinne Chureau,Yojiro Yamanaka,Edith Heard,Richard L. Gardner,Philip Avner,Janet Rossant,Janet Rossant +11 more
TL;DR: Based on gene expression analysis, chimera studies and imprinted X-inactivation, XEN cell lines are representative of extra-embryonic endoderm and provide a new cell culture model of an early mammalian lineage.
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Investigation of the fate of 4.5 Day post-coitum mouse inner cell mass cells by blastocyst injection.
Richard L. Gardner,J. Rossant +1 more
TL;DR: The results, together with those of previous studies, suggest that the entire foetus, including its endodermal components, is formed from the primitive ectoderm, and that primitive endoderm forms only extra-embryonicendoderm of the conceptus.