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Richard P. Metz
Researcher at Texas A&M University
Publications - 80
Citations - 3890
Richard P. Metz is an academic researcher from Texas A&M University. The author has contributed to research in topics: Population & Mammary gland. The author has an hindex of 31, co-authored 76 publications receiving 3290 citations. Previous affiliations of Richard P. Metz include Texas College & Lanzhou University.
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Journal ArticleDOI
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
Alban Bessede,Alban Bessede,Marco Gargaro,Maria Teresa Pallotta,Davide Matino,Giuseppe Servillo,Cinzia Brunacci,Silvio Bicciato,Emilia Maria Cristina Mazza,Antonio Macchiarulo,Carmine Vacca,Rossana G. Iannitti,Luciana Tissi,Claudia Volpi,Maria Laura Belladonna,Ciriana Orabona,Roberta Bianchi,Tobias V. Lanz,Michael Platten,Maria Agnese Della Fazia,Danilo Piobbico,Teresa Zelante,Hiroshi Funakoshi,Toshikazu Nakamura,David Gilot,Michael S. Denison,Gilles J. Guillemin,James B. DuHadaway,George C. Prendergast,Richard P. Metz,Michel Geffard,Louis Boon,Matteo Pirro,Alfonso Iorio,Bernard Veyret,Luigina Romani,Ursula Grohmann,Francesca Fallarino,Paolo Puccetti +38 more
TL;DR: It was found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to downregulate early inflammatory gene expression, pointing to a role for AhR in contributing to host fitness.
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Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer
George C. Prendergast,George C. Prendergast,Courtney Smith,Sunil Thomas,Laura Mandik-Nayak,Lisa Laury-Kleintop,Richard P. Metz,Alexander J. Muller,Alexander J. Muller +8 more
TL;DR: A personal perspective on IDO as a nodal mediator of pathogenic inflammation and immune escape in cancer is provided to provide a conceptual foundation for the clinical development of IDO inhibitors as a novel class of immunomodulators with broad application in the treatment of advanced human cancer.
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IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
Courtney Smith,Mee Young Chang,Katherine H. Parker,Daniel W. Beury,James B. DuHadaway,Hollie E. Flick,Janette Boulden,Erika Sutanto-Ward,Alejandro Peralta Soler,Lisa Laury-Kleintop,Laura Mandik-Nayak,Richard P. Metz,Suzanne Ostrand-Rosenberg,George C. Prendergast,Alexander J. Muller +14 more
TL;DR: This study provides preclinical, genetic proof-of-concept that the immunoregulatory enzyme IDO contributes to autochthonous carcinoma progression and to the creation of a metastatic niche.
Journal ArticleDOI
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis.
Shauntae M. McDaniel,Kristen K. Rumer,Sandra L. Biroc,Richard P. Metz,Meenakshi Singh,Weston Porter,Pepper Schedin +6 more
TL;DR: It is suggested that the mammary gland microenvironment becomes promotional for tumor cell dissemination during involution, thus providing a plausible mechanism to explain the high rate of metastases that occur with pregnancy-associated breast cancer.
Journal ArticleDOI
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
Richard P. Metz,Courtney Smith,James B. DuHadaway,Phillip Chandler,Babak Baban,Lauren M.F. Merlo,Elizabeth Pigott,Martin P. Keough,Sonja Rust,Andrew L. Mellor,Laura Mandik-Nayak,Laura Mandik-Nayak,Alexander J. Muller,Alexander J. Muller,George C. Prendergast,George C. Prendergast +15 more
TL;DR: These results offer an initial glimpse into immune modulation by IDO2, revealing its genetic interaction with IDO1 and distinguishing its non-redundant contributions to inflammation, and establishing a functional role for Ido2 in immune modulation.