M
Maria Laura Belladonna
Researcher at University of Perugia
Publications - 92
Citations - 10786
Maria Laura Belladonna is an academic researcher from University of Perugia. The author has contributed to research in topics: Interleukin 12 & CD8. The author has an hindex of 42, co-authored 88 publications receiving 9895 citations. Previous affiliations of Maria Laura Belladonna include Sapporo Medical University & Cedars-Sinai Medical Center.
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Journal ArticleDOI
Modulation of tryptophan catabolism by regulatory T cells.
Francesca Fallarino,Ursula Grohmann,Kwang Woo Hwang,Ciriana Orabona,Carmine Vacca,Roberta Bianchi,Maria Laura Belladonna,Maria C. Fioretti,Maria-Luisa Alegre,Paolo Puccetti +9 more
TL;DR: It is shown that mouse CD4+CD25+ cells, either resting or induced to overexpress CTLA-4 by treatment with antibody to CD3, initiated tryptophan catabolism in dendritic cells through a CT LA-4-dependent mechanism, which might represent a major mechanism of action of TR cells.
Journal ArticleDOI
CTLA-4-Ig regulates tryptophan catabolism in vivo.
Ursula Grohmann,Ciriana Orabona,Francesca Fallarino,Carmine Vacca,Filippo Calcinaro,Alberto Falorni,Paola Candeloro,Maria Laura Belladonna,Roberta Bianchi,Maria C. Fioretti,Paolo Puccetti +10 more
TL;DR: It is shown that long-term survival of pancreatic islet allografts induced by the soluble fusion protein CTLA-4–immunoglobulin (CTLA- 4–Ig) is contingent upon effective tryptophan catabolism in the host and that CTla-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals.
Journal ArticleDOI
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells
Francesca Fallarino,Ursula Grohmann,Sylvaine You,Barbara C. McGrath,Douglas R. Cavener,Carmine Vacca,Ciriana Orabona,Roberta Bianchi,Maria Laura Belladonna,Claudia Volpi,Pere Santamaria,Maria C. Fioretti,Paolo Puccetti +12 more
TL;DR: Evidence is provided that the short-term, combined effects of tryptophan deprivation and tryPTophan catabolites result in GCN2 kinase-dependent down-regulation of the TCR ζ-chain in murine CD8+ T cells.
Journal ArticleDOI
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
Maria Teresa Pallotta,Ciriana Orabona,Claudia Volpi,Carmine Vacca,Maria Laura Belladonna,Roberta Bianchi,Giuseppe Servillo,Cinzia Brunacci,Mario Calvitti,Silvio Bicciato,Emilia Maria Cristina Mazza,Louis Boon,Fabio Grassi,Maria C. Fioretti,Francesca Fallarino,Paolo Puccetti,Ursula Grohmann +16 more
TL;DR: It is found that IDO was involved in intracellular signaling events responsible for the self-amplification and maintenance of a stably regulatory phenotype in pDCs and has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts.
Journal ArticleDOI
IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
Teresa Zelante,Antonella De Luca,Pierluigi Bonifazi,Claudia Montagnoli,Silvia Bozza,Silvia Moretti,Maria Laura Belladonna,Carmine Vacca,Carmela Conte,Paolo Mosci,Francesco Bistoni,Paolo Puccetti,Robert A. Kastelein,Manfred Kopf,Luigina Romani +14 more
TL;DR: The data are the first demonstrating that the IL‐23/IL‐17 pathway promotes inflammation and susceptibility in an infectious disease model and modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi.