Sam Michael

TL;DR: A high-throughput screening platform capable of testing compounds in pairwise matrix blocks for the rapid and systematic identification of synergistic, additive, and antagonistic drug combinations for diffuse large B-cell lymphoma (DLBCL).

TL;DR: The N3C has demonstrated that a multisite collaborative learning health network can overcome barriers to rapidly build a scalable infrastructure incorporating multiorganizational clinical data for COVID-19 analytics.

TL;DR: The Tox21 screening process, compound library preparation, data processing, and robotic system validation are described, which is capable of screening and profiling the collection of 10K environmental chemicals in triplicate in a week.

TL;DR: Novel small molecule inhibitors of FOXM1 that block DNA binding are identified from a high-throughput screen applied to a library of 54,211 small molecules and one of the identified compounds, FDI-6, is characterized in depth and is shown to bind directly toFOXM1 protein, to displace FOXM 1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

TL;DR: A multiplexed quantitative high throughput screening approach was used to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP.