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Richard W. Padgett
Researcher at Rutgers University
Publications - 53
Citations - 4946
Richard W. Padgett is an academic researcher from Rutgers University. The author has contributed to research in topics: Signal transduction & Caenorhabditis elegans. The author has an hindex of 30, co-authored 53 publications receiving 4683 citations.
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Methylation as a Crucial Step in Plant microRNA Biogenesis
Bin Yu,Zhiyong Yang,Junjie Li,Svetlana Minakhina,Maocheng Yang,Richard W. Padgett,Ruth Steward,Xuemei Chen +7 more
TL;DR: It is shown that plant microRNAs (miRNAs) have a naturally occurring methyl group on the ribose of the last nucleotide, a new and crucial step in plant miRNA biogenesis and have profound implications in the function of miRNAs.
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Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.
Cathy Savage,Pradeep Das,Alyce L. Finelli,Scott R. Townsend,Ching-Yu Sun,Scott Everet Baird,Richard W. Padgett +6 more
TL;DR: The identification of homologous components of these pathways in distantly related organisms suggests that dwarfins may be universally required for TGF-beta-like signal transduction, and isolated highly conserved dwarfins from vertebrates, indicating that these components are not idiosyncratic to invertebrates.
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Incorporating structure to predict microRNA targets
TL;DR: An algorithm for predicting targets that does not rely on evolutionary conservation is developed that incorporates the folded structure of mRNA by using Drosophila miRNAs as a test case and is validated in 10 of 15 genes tested.
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TGFβ-related pathways: roles in Caenorhabditis elegans development
TL;DR: The insights that have come from standard molecular genetic experiments are reviewed and how the recently completed genome sequence has contributed to understanding of TGFβ-related pathways are discussed.
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A bmp homolog acts as a dose-dependent regulator of body size and male tail patterning in caenorhabditis elegans
Yo Suzuki,Mark Yandell,Mark Yandell,Peter J. Roy,Srikant Krishna,Cathy Savage-Dunn,Cathy Savage-Dunn,Robert Mars Ross,Richard W. Padgett,William B. Wood +9 more
TL;DR: The cloned dbl-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes, suggests a role for neuronal cells in global size regulation as well as male tail patterning.