R
Riina Oksjoki
Researcher at Forest Research Institute
Publications - 12
Citations - 765
Riina Oksjoki is an academic researcher from Forest Research Institute. The author has contributed to research in topics: Complement system & Inflammation. The author has an hindex of 10, co-authored 10 publications receiving 721 citations.
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Journal ArticleDOI
Role of complement activation in atherosclerosis.
TL;DR: In humans there is extensive circumstantial evidence for a role of complement in Atherosclerosis, which is somewhat contradictory to recent modest or negative findings in atherosclerosis-prone genetically engineered hyperlipidemic mice.
Journal ArticleDOI
Lipoprotein Lipase in the Arterial Wall Linking LDL to the Arterial Extracellular Matrix and Much More
TL;DR: The structures in the extracellular matrix that are held to be important in this process are described, and the potentially harmful consequences of LDL linking by LPL and of other LPL actions in the arterial intima are briefly reviewed.
Journal ArticleDOI
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques
Riina Oksjoki,Petri Laine,Satu Helske,Pirjo Vehmaan-Kreula,Mikko I. Mäyränpää,Philippe Gasque,Petri T. Kovanen,Markku O. Pentikäinen +7 more
TL;DR: The presence of receptors for anaphylatoxin receptors C3aR and C5aR in human coronary plaques suggests that anaphyllatoxins activate coronary plaque, and points the complement system as a potential therapeutic target in attempts to stabilize them.
Journal ArticleDOI
Function and regulation of the complement system in cardiovascular diseases.
TL;DR: Evidence derived mainly from experimental animals suggesting that modulation of complement activation may alter the course of these disorders is discussed, suggesting that limitation of excessive complement activation under these conditions may hold therapeutic value.
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Association Between Complement Factor H and Proteoglycans in Early Human Coronary Atherosclerotic Lesions. Implications for Local Regulation of Complement Activation
TL;DR: The present observations raise the possibility that proteoglycans, because of their ability to bind the major complement inhibitor factor H, may inhibit complement activation in the superficial layer of the arterial intima.