R
Rima Rozen
Researcher at McGill University
Publications - 213
Citations - 26523
Rima Rozen is an academic researcher from McGill University. The author has contributed to research in topics: Methylenetetrahydrofolate reductase & Homocysteine. The author has an hindex of 64, co-authored 212 publications receiving 25630 citations. Previous affiliations of Rima Rozen include National Center for Toxicological Research & University of Calgary.
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Journal ArticleDOI
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Jacquetta M. Trasler,Liyuan Deng,Stepan Melnyk,Igor P. Pogribny,Francois Hiou-Tim,Sahar Sibani,Christopher C. Oakes,En Li,S. Jill James,Rima Rozen +9 more
TL;DR: Genetic deficiency in Dnmt1 with or without folate deficiency decreases tumor number in the Apc(Min) mouse model, but this effect may not be mediated by changes in SAM or SAH levels, nor by alterations in global methylation in the pre-neoplastic intestinal tissue.
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Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
Bernd Schwahn,Bernd Schwahn,M. D. Laryea,Zhoutao Chen,Stepan Melnyk,Igor P. Pogribny,Timothy A. Garrow,S. Jill James,Rima Rozen +8 more
TL;DR: An important role for choline and betaine depletion in the pathogenesis of homocystinuria due to MTHFR deficiency is emphasized, and the dramatic effects of betaine on survival and growth are emphasized.
Journal ArticleDOI
Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children
TL;DR: The data show that in a healthy pediatric population, MTHFR genotype played a significant role in determining homocysteine concentrations in older (>10 y), nutritionally stressed children.
Journal ArticleDOI
Oncogenic role of PDK4 in human colon cancer cells
Daniel Leclerc,D N T Pham,Nancy Lévesque,M Truongcao,William D. Foulkes,Carmen Sapienza,Rima Rozen +6 more
TL;DR: Methylation assessment of PDK4 in the blood may be useful for non-invasive CRC detection and should be considered as a target for development of anticancer strategies and therapies.
Journal ArticleDOI
Translational control of ornithine aminotransferase. Modulation by initiation factor eIF-4E.
TL;DR: To examine the regulatory mechanisms in these cell lines, nuclear runoff experiments and characterized polysome-associated OAT mRNAs were performed and the nuclear runoff data did not reveal any differences in transcription between the two strains.