R
Rima Rozen
Researcher at McGill University
Publications - 213
Citations - 26523
Rima Rozen is an academic researcher from McGill University. The author has contributed to research in topics: Methylenetetrahydrofolate reductase & Homocysteine. The author has an hindex of 64, co-authored 212 publications receiving 25630 citations. Previous affiliations of Rima Rozen include National Center for Toxicological Research & University of Calgary.
Papers
More filters
Journal ArticleDOI
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.
Yan Luan,Daniel Leclerc,Marta Cosín-Tomás,Olga V. Malysheva,Brandi Wasek,Teodoro Bottiglieri,Marie A. Caudill,Rima Rozen +7 more
TL;DR: In this article, the authors reported that diets containing 5-fold higher FA than recommended for mice (5xFASD) during pregnancy, resulted in methylenetetetrahydrofolate reductase deficiency and altered choline/methyl metabolism, with neurobehavioral abnormalities in newborns.
Journal ArticleDOI
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
TL;DR: The structure of this paralogous gene and the identification of a repeat sequence at the 3′ end of this pseudogene suggest that it arose by retrotransposition of a mis-spliced Mthfr transcript.
Journal ArticleDOI
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Karen E. Christensen,Renata H. Bahous,Wenyang Hou,Liyuan Deng,Olga V. Malysheva,Erland Arning,Teodoro Bottiglieri,Marie A. Caudill,Loydie A. Jerome-Majewska,Rima Rozen +9 more
TL;DR: MTHFD1 synthetase-deficient mice are more sensitive to low folate intake than wild-type mice during pregnancy, and reduced purine synthesis due to synthet enzyme deficiency and altered methylation potential due toLow folate may increase pregnancy complications.
Journal ArticleDOI
High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis.
TL;DR: This work suggests that high folic acid consumption disturbs cholesterol homeostasis in liver, and may have particular relevance for MTHFR-deficient individuals, who represent ∼10% of many populations.