R
Rima Rozen
Researcher at McGill University
Publications - 213
Citations - 26523
Rima Rozen is an academic researcher from McGill University. The author has contributed to research in topics: Methylenetetrahydrofolate reductase & Homocysteine. The author has an hindex of 64, co-authored 212 publications receiving 25630 citations. Previous affiliations of Rima Rozen include National Center for Toxicological Research & University of Calgary.
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Journal ArticleDOI
A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease
TL;DR: The findings suggest that the GG genotype of MTRR is a significant risk factor for the development of premature CAD, by a mechanism independent of the detrimental vascular effects of hyperhomocysteinemia.
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Molecular genetics of cystinuria: Mutation analysis of SLC3A1 and evidence for another gene in the Type I (silent) phenotype
Irfan Saadi,Xing-Zhen Chen,Xing-Zhen Chen,Matthias Hediger,Matthias Hediger,Patricia Ong,Patricia Ong,Perpetual Pereira,Perpetual Pereira,Paul Goodyer,Paul Goodyer,Rima Rozen,Rima Rozen +12 more
TL;DR: It is proposed that the Type I phenotype could be caused by mutations in other, as yet unidentified cystinuria genes.
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Moderately high intake of folic acid has a negative impact on mouse embryonic development
TL;DR: Maternal FA supplementation was associated with embryonic loss, embryonic delays, a higher incidence of ventricular septal defects, and thinner left and right ventricular walls, compared to mothers fed control diet.
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Cystic fibrosis mutations in French Canadians: three CFTR mutations are relatively frequent in a Quebec population with an elevated incidence of cystic fibrosis.
Rima Rozen,Marc De Braekeleer,J Daigneault,Leonor Ferreira-Rajabi,Maria Gerdes,Linda Lamoureux,G Aubin,F Simard,T. Mary Fujiwara,Kenneth Morgan +9 more
TL;DR: Results provide evidence for the role of founder effect in the elevated incidence of cystic fibrosis in the Saguenay-Lac St. Jean population.
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Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.
Isabelle Morin,Angela M. Devlin,Daniel Leclerc,Nelly Sabbaghian,Charles H. Halsted,Richard H. Finnell,Rima Rozen +6 more
TL;DR: This small study is the first to demonstrate increased risk for women with the RFC-1 variant for having a child with a NTD, and additional larger studies are required to confirm this change as another potential genetic modifier for spina bifida risk.