R
Rithy Sem
Researcher at Pasteur Institute
Publications - 16
Citations - 1417
Rithy Sem is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Plasmodium falciparum & Mefloquine. The author has an hindex of 15, co-authored 16 publications receiving 1348 citations.
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Journal ArticleDOI
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.
William O. Rogers,Rithy Sem,Thong Tero,Pheaktra Chim,Pharath Lim,Sinuon Muth,Duong Socheat,Frédéric Ariey,Chansuda Wongsrichanalai +8 more
TL;DR: The results suggest that artesunate-mefloquine combination therapy is beginning to fail in southern Cambodia and that resistance is not confined to the provinces at the Thai-Cambodian border.
Journal ArticleDOI
Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the cambodian–thai border
Alisa P. Alker,Pharath Lim,Rithy Sem,Naman K. Shah,Poravuth Yi,Denis Mey Bouth,Reiko Tsuyuoka,Jason D. Maguire,Thierry Fandeur,Frédéric Ariey,Chansuda Wongsrichanalai,Steven R. Meshnick +11 more
TL;DR: Artemisinin combination therapies have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries and should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia.
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Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia.
Mey Bouth Denis,Reiko Tsuyuoka,Yi Poravuth,Top Sophoan Narann,Suon Seila,Chim Lim,Sandra Incardona,Pharath Lim,Rithy Sem,Duong Socheat,Eva Christophel,Pascal Ringwald +11 more
TL;DR: Artesunate and mefloquine combination treatment has been used since 2000 in Cambodia as the first‐line drug for the treatment of uncomplicated falciparum malaria and side effects were common, especially dizziness, but were mild and transient and patients recovered without any medical intervention.
Journal ArticleDOI
Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.
Jonathan J. Juliano,Kimberly A. Porter,Victor Mwapasa,Rithy Sem,William O. Rogers,Frédéric Ariey,Chansuda Wongsrichanalai,Andrew F. Read,Steven R. Meshnick +8 more
TL;DR: In this paper, the authors used massively parallel pyrosequencing to characterize malaria parasite diversity in the infections of a group of patients and showed that the in-host diversity revealed by this method far exceeded that described by currently recommended genotyping methods, with as many as sixfold more variants per infection.
Journal ArticleDOI
Origin and evolution of sulfadoxine resistant Plasmodium falciparum.
Sumiti Vinayak,Tauqeer Alam,Tonya Mixson-Hayden,Andrea M. McCollum,Rithy Sem,Naman K. Shah,Pharath Lim,Sinuon Muth,William O. Rogers,Thierry Fandeur,John W. Barnwell,Ananias A. Escalante,Chansuda Wongsrichanalai,Frederick Ariey,Steven R. Meshnick,Venkatachalam Udhayakumar +15 more
TL;DR: Comparative analysis of the microsatellite haplotypes flanking dhps alleles from Cambodia, Kenya, Cameroon and Venezuela revealed an independent origin of sulfadoxine resistant alleles in each of these regions.