P
Pheaktra Chim
Researcher at Pasteur Institute
Publications - 14
Citations - 1371
Pheaktra Chim is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 10, co-authored 14 publications receiving 1223 citations.
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Journal ArticleDOI
Novel phenotypic assays for the detection of artemisinin- resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
Benoit Witkowski,Chanaki Amaratunga,Nimol Khim,Sokunthea Sreng,Pheaktra Chim,Saorin Kim,Pharath Lim,Pharath Lim,Sivanna Mao,Chantha Sopha,Baramey Sam,Jennifer M. Anderson,Socheat Duong,Char Meng Chuor,Walter R. J. Taylor,Seila Suon,Odile Mercereau-Puijalon,Rick M. Fairhurst,Didier Menard +18 more
TL;DR: The in-vitro RSA of 0-3 h ring-stage parasites provides a platform for the molecular characterisation of artemisinin resistance and the ex-vivo RSA can be easily implemented where surveillance for artemis inin resistance is needed.
Journal ArticleDOI
Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia
Benoit Witkowski,Nimol Khim,Pheaktra Chim,Saorin Kim,Sopheakvatey Ke,Nimol Kloeung,Sophie Chy,Socheat Duong,Rithea Leang,Pascal Ringwald,Arjen M. Dondorp,Rupam Tripura,Françoise Benoit-Vical,Antoine Berry,Olivier Gorgette,Frédéric Ariey,Jean-Christophe Barale,Odile Mercereau-Puijalon,Didier Menard +18 more
TL;DR: The reduced susceptibility to artemisinin in Pailin appears to be associated with an altered in vitro phenotype of ring stages from Pailsin in the RSA, which is associated with a clear-cut geographic dichotomy.
Journal ArticleDOI
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.
William O. Rogers,Rithy Sem,Thong Tero,Pheaktra Chim,Pharath Lim,Sinuon Muth,Duong Socheat,Frédéric Ariey,Chansuda Wongsrichanalai +8 more
TL;DR: The results suggest that artesunate-mefloquine combination therapy is beginning to fail in southern Cambodia and that resistance is not confined to the provinces at the Thai-Cambodian border.
Journal ArticleDOI
Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains.
Didier Menard,Ernest R. Chan,Christophe Benedet,Arsène Ratsimbasoa,Saorin Kim,Pheaktra Chim,Catherine Do,Benoit Witkowski,Rémy Durand,Marc Thellier,Carlo Severini,Eric Legrand,Lise Musset,Bakri Y. M. Nour,Odile Mercereau-Puijalon,David Serre,Peter A. Zimmerman +16 more
TL;DR: The discovery of a duplication of the P. vivax Duffy binding protein (PvDBP) gene suggests that PvDBP, a merozoite surface protein involved in red cell adhesion is rapidly evolving, possibly in response to constraints imposed by erythrocyte Duffy negativity in some human populations.
Journal ArticleDOI
Decreased In Vitro Susceptibility of Plasmodium falciparum Isolates to Artesunate, Mefloquine, Chloroquine, and Quinine in Cambodia from 2001 to 2007
Pharath Lim,Chansuda Wongsrichanalai,Pheaktra Chim,Nimol Khim,Saorin Kim,Sophy Chy,Rithy Sem,Sina Nhem,Poravuth Yi,Socheat Duong,Denis Mey Bouth,Blaise Genton,Hans-Peter Beck,Jean Gerard Gobert,William O. Rogers,Jean-Yves Coppée,Thierry Fandeur,Odile Mercereau-Puijalon,Pascal Ringwald,Jacques Le Bras,Frédéric Ariey +20 more
TL;DR: The GMIC50s of the four drugs tested increased significantly in eastern Cambodia during 2006 to 2007, which may signal deterioration of the efficacy of artesunate-mefloquine beyond the Cambodian-Thai border.