S
Sumiti Vinayak
Researcher at University of Illinois at Urbana–Champaign
Publications - 30
Citations - 1434
Sumiti Vinayak is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Cryptosporidium parvum & Plasmodium falciparum. The author has an hindex of 17, co-authored 29 publications receiving 1200 citations. Previous affiliations of Sumiti Vinayak include Veterans Health Administration & Centers for Disease Control and Prevention.
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Journal ArticleDOI
Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum
Sumiti Vinayak,Mattie C. Pawlowic,Adam Sateriale,Carrie F. Brooks,Caleb J. Studstill,Yael Bar-Peled,Michael J. Cipriano,Boris Striepen +7 more
TL;DR: The ability to genetically engineer this parasite will be transformative for Cryptosporidium research and genetic reporters will provide quantitative correlates for disease, cure and protection, and the role of parasite genes in these processes is now open to rigorous investigation.
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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
Ujjini H. Manjunatha,Sumiti Vinayak,Jennifer A. Zambriski,Alex Chao,Tracy Sy,Christian G. Noble,Ghislain M. C. Bonamy,Ravinder Reddy Kondreddi,Bin Zou,Peter Gedeck,Carrie F. Brooks,Gillian T. Herbert,Adam Sateriale,Jayesh Tandel,Susan Noh,Suresh B. Lakshminarayana,Siau H. Lim,Laura B. Goodman,Christophe Bodenreider,Gu Feng,Lijun Zhang,Francesca Blasco,Juergen Wagner,F. Joel Leong,Boris Striepen,Thierry T. Diagana +25 more
TL;DR: The results suggest that the Cryptosporidium lipid kinase PI(4)K (phosphatidylinositol-4-OH kinase) is a target for pyrazolopyridines and that KDU731 warrants further preclinical evaluation as a drug candidate for the treatment of cryptosporidiosis.
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Origin and evolution of sulfadoxine resistant Plasmodium falciparum.
Sumiti Vinayak,Tauqeer Alam,Tonya Mixson-Hayden,Andrea M. McCollum,Rithy Sem,Naman K. Shah,Pharath Lim,Sinuon Muth,William O. Rogers,Thierry Fandeur,John W. Barnwell,Ananias A. Escalante,Chansuda Wongsrichanalai,Frederick Ariey,Steven R. Meshnick,Venkatachalam Udhayakumar +15 more
TL;DR: Comparative analysis of the microsatellite haplotypes flanking dhps alleles from Cambodia, Kenya, Cameroon and Venezuela revealed an independent origin of sulfadoxine resistant alleles in each of these regions.
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Plasmodium falciparum Isolates in India Exhibit a Progressive Increase in Mutations Associated with Sulfadoxine-Pyrimethamine Resistance
Anwar Ahmed,Deepak Bararia,Sumiti Vinayak,Mohammed Yameen,Sukla Biswas,Vas Dev,Ashwani Kumar,Musharraf A. Ansari,Yagya D. Sharma +8 more
TL;DR: It was concluded that even though SP is prescribed as a second line of treatment in India, the mutations associated with SP resistance continue to be progressively increasing.
Journal ArticleDOI
Selective Sweeps and Genetic Lineages of Plasmodium falciparum Drug -Resistant Alleles in Ghana
Tauqeer Alam,Tauqeer Alam,Dziedzom K. de Souza,Sumiti Vinayak,Sumiti Vinayak,Sean M. Griffing,Sean M. Griffing,Sean M. Griffing,Amanda Poe,Amanda Poe,Nancy O. Duah,Anita Ghansah,Kwame Asamoa,Laurence Slutsker,Michael D. Wilson,John W. Barnwell,Venkatachalam Udhayakumar,Kwadwo A. Koram +17 more
TL;DR: A comprehensive study of the drug-resistance-associated mutations and their genetic lineages in Ghana will lead to a better understanding of the evolution of antimalarial drug resistance in this region.