W
William O. Rogers
Researcher at Naval Medical Research Center
Publications - 67
Citations - 4989
William O. Rogers is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 34, co-authored 65 publications receiving 4604 citations. Previous affiliations of William O. Rogers include Eijkman Institute for Molecular Biology & Albert Einstein College of Medicine.
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Journal ArticleDOI
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frédéric Ariey,Benoit Witkowski,Chanaki Amaratunga,Johann Beghain,Anne-Claire Langlois,Nimol Khim,Saorin Kim,Valentine Duru,Christiane Bouchier,Laurence Ma,Pharath Lim,Rithea Leang,Socheat Duong,Sokunthea Sreng,Seila Suon,Char Meng Chuor,Denis Mey Bout,Sandie Menard,William O. Rogers,Blaise Genton,Thierry Fandeur,Olivo Miotto,Pascal Ringwald,Jacques Le Bras,Antoine Berry,Jean Christophe Barale,Rick M. Fairhurst,Françoise Benoit-Vical,Odile Mercereau-Puijalon,Didier Menard +29 more
TL;DR: Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance.
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Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.
William O. Rogers,Rithy Sem,Thong Tero,Pheaktra Chim,Pharath Lim,Sinuon Muth,Duong Socheat,Frédéric Ariey,Chansuda Wongsrichanalai +8 more
TL;DR: The results suggest that artesunate-mefloquine combination therapy is beginning to fail in southern Cambodia and that resistance is not confined to the provinces at the Thai-Cambodian border.
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Characterization of Plasmodium falciparum sporozoite surface protein 2.
William O. Rogers,Anita Malik,Sylvie Mellouk,Kenichiro Nakamura,Miriam D. Rogers,Ana Szarfman,Daniel M. Gordon,Andreas K. Nussler,Masamichi Aikawa,Stephen L. Hoffman +9 more
TL;DR: Human volunteers immunized with irradiated sporozoites and protected against malaria develop antibody and proliferative T-cell responses to PfSSP2, suggesting that, like PySSP 2, PfS SP2 is a target of protective immunity, and supporting inclusion of PfSSPA2 in a multicomponent malaria vaccine.
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Codon optimization of gene fragments encoding Plasmodium falciparum merzoite proteins enhances DNA vaccine protein expression and immunogenicity in mice.
David L. Narum,Sanjai Kumar,William O. Rogers,Steven R. Fuhrmann,Hong Liang,Miranda S. Oakley,Alem Taye,B. Kim Lee Sim,Stephen L. Hoffman +8 more
TL;DR: It is demonstrated that optimizing codon usage in DNA vaccines can improve protein expression and consequently the immunogenicity of gene fragments in DNA vaccine plasmids for organisms whosecodon usage differs substantially from that of mammals.
Journal ArticleDOI
Malaria transmission dynamics at a site in northern Ghana proposed for testing malaria vaccines
Maxwell A. Appawu,Seth Owusu-Agyei,Samuel Dadzie,Victor Asoala,Francis Anto,Kwadwo A. Koram,William O. Rogers,Francis K. Nkrumah,Stephen L. Hoffman,David J. Fryauff +9 more
TL;DR: The malaria transmission dynamics in Kassena Nankana district (KND), a site in northern Ghana proposed for testing malaria vaccines, was studied, with timing dependent on the seasonal patterns and intensity of transmission taking into consideration the micro‐geographical differences and vaccine trial objectives.