Poravuth Yi

TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.

TL;DR: In this article, the authors used a two-phase strategy to identify genome regions(s) underlying this ongoing selective event and identified a selective sweep on chromosome 13 that shows strong association (P = 10−6) to 10−12) with slow Artemisinin-resistant parasites.

TL;DR: Artemisinin combination therapies have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries and should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia.

TL;DR: The decreased metabolic activities in the ring stages are consistent with previous suggestions of higher resilience of the early developmental stages to artemisinin and the increased capacity of protein synthesis and protein turnover in the schizont stage may contribute to art Artemisinin resistance by counteracting the protein damage caused by the oxidative stress and/or protein alkylation effect of this drug.

TL;DR: This study shows that pfmdr1 copy number is a molecular marker of AM treatment failure in falciparum malaria on the Thai-Cambodian border, however, while it is associated with increased IC50 for lumefantrine, pfmDr1copy number is not associated with AL treatment failure on the area, suggesting involvement of other molecular mechanisms in AL treatment failures in Cambodia.