R
Rizi Ai
Researcher at University of California, San Diego
Publications - 30
Citations - 1593
Rizi Ai is an academic researcher from University of California, San Diego. The author has contributed to research in topics: DNA methylation & Arthritis. The author has an hindex of 14, co-authored 25 publications receiving 1196 citations. Previous affiliations of Rizi Ai include University of California, Riverside & University of California, Los Angeles.
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Journal ArticleDOI
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Blue B. Lake,Rizi Ai,Gwendolyn E. Kaeser,Gwendolyn E. Kaeser,Neeraj Salathia,Yun C. Yung,Rui Liu,Andre Wildberg,Derek Gao,Ho-Lim Fung,Song Chen,Raakhee Vijayaraghavan,Julian Wong,Allison Chen,Xiaoyan Sheng,Fiona Kaper,Richard Shen,Mostafa Ronaghi,Jian-Bing Fan,Wei Wang,Jerold Chun,Kun Zhang +21 more
TL;DR: A scalable approach to sequence and quantify RNA molecules in isolated neuronal nuclei from a postmortem brain, generating 3227 sets of single-neuron data from six distinct regions of the cerebral cortex demonstrates a robust and scalable method for identifying and categorizing single nuclear transcriptomes.
Journal ArticleDOI
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
Rizi Ai,Teresina Laragione,Deepa Hammaker,David L. Boyle,Andre Wildberg,Keisuke Maeshima,Emanuele Palescandolo,Vinod Krishna,David Pocalyko,John W. Whitaker,Yuchen Bai,Sunil Nagpal,Kurtis E. Bachman,Richard I. Ainsworth,Mengchi Wang,Bo Ding,Pércio S. Gulko,Wei Wang,Gary S. Firestein +18 more
TL;DR: A variety of epigenomic data is integrated to map the epigenome of FLS in RA and identify potential therapeutic targets, establishing a high-resolution epigenomic landscape of RA and demonstrating the potential for integrative analyses to identify unanticipated therapeutic targets.
Journal ArticleDOI
Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
Rizi Ai,Deepa Hammaker,David L. Boyle,Rachel Morgan,Alice M. Walsh,Shicai Fan,Shicai Fan,Gary S. Firestein,Wei Wang +8 more
TL;DR: It is shown that distinct DNA methylation and transcriptome signatures not only discriminate RA fibroblast-like synoviocytes from osteoarthritis FLS, but also distinguish RA FLS isolated from knees and hips.
Journal ArticleDOI
Normalization and noise reduction for single cell RNA-seq experiments
TL;DR: A powerful but simple method to remove technical noise and explicitly compute the true gene expression levels based on spike-in ERCC molecules is presented.
Journal ArticleDOI
DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis
Rizi Ai,John W. Whitaker,David L. Boyle,Paul P. Tak,Danielle M. Gerlag,Wei Wang,Gary S. Firestein +6 more
TL;DR: To understand when alterations in DNA methylation occur in RA and the specificity of the methylation changes in RA, differentially methylated loci (DMLs) of early RA, juvenile idiopathic arthritis (JIA) to longstanding RA (LRA) and osteoarthritis (OA) are compared.