Richard Shen

TL;DR: The ability to determine genome-wide methylation patterns will rapidly advance methylation research.

TL;DR: A scalable approach to sequence and quantify RNA molecules in isolated neuronal nuclei from a postmortem brain, generating 3227 sets of single-neuron data from six distinct regions of the cerebral cortex demonstrates a robust and scalable method for identifying and categorizing single nuclear transcriptomes.

TL;DR: An integrated SNP genotyping system that combines a highly multiplexed assay with an accurate readout technology based on random arrays of DNA-coated beads is developed that helps enable genome-wide association studies and other large-scale genetic analysis projects.

TL;DR: The application of Infinium genotyping technology to analyze bisulfite-converted DNA to simultaneously query the methylation state of over 27,000 CpG sites from promoters of consensus coding sequences (CCDS) genes demonstrates a genome-wide scalable array-based methylation readout platform that is both highly reproducible and quantitative.

TL;DR: The utility of SNP-CGH is demonstrated with two Infinium whole-genome genotyping BeadChips, assaying 109,000 and 317,000 SNP loci, and the statistical ability to detect common aberrations was modeled by analysis of an X chromosome titration model system, and sensitivity was modeling by titration of gDNA from a tumor cell with that of its paired normal cell line.