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Conrad C. Bleul
Researcher at Harvard University
Publications - 9
Citations - 6985
Conrad C. Bleul is an academic researcher from Harvard University. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 8, co-authored 8 publications receiving 6821 citations.
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Journal ArticleDOI
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Conrad C. Bleul,Michael Farzan,Hyeryun Choe,Cristina Parolin,Cristina Parolin,Ian Clark-Lewis,Joseph Sodroski,Timothy A. Springer +7 more
TL;DR: Testing of potential receptors demonstrated that SDF-1 signalled through, and hence 'adopted', the orphan receptor LESTR, which is therefore designated CXC-chemokine receptor-4 (CXCR-4).
Journal ArticleDOI
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Conrad C. Bleul,Robert C. Fuhlbrigge,José M. Casasnovas,Alessandro Aiuti,Timothy A. Springer +4 more
TL;DR: A highly efficacious lymphocytes chemotactic activity in the supernatants of the murine bone marrow stroma cell line MS-5 is identified which attracts 10-fold more lymphocytes in vitro than currently described lymphocyte chemoattractants.
Journal ArticleDOI
The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood
TL;DR: Hematopoietic progenitor cells migrate in vitro and in vivo towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced byStromal cells, the first chemoattractant reported for human CD34+ progenitors.
Journal ArticleDOI
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
TL;DR: The largely reciprocal expression of CXCR4 and CCR5 among peripheral blood T cells implies distinct susceptibility of T cell subsets to viral entry by T cell line- Tropic versus macrophage-tropic strains during the course of HIV infection.
Journal ArticleDOI
Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin
Takashi Nagasawa,Toshihiro Nakajima,Kazunobu Tachibana,Hisashi Iizasa,Conrad C. Bleul,Osamu Yoshie,Kouji Matsushima,Nobuaki Yoshida,Timothy A. Springer,Tadamitsu Kishimoto +9 more
TL;DR: PB-CKR will be an important tool for functional mapping of HIV-1 entry coreceptor fusin and for understanding the function of PBSF/SDF-1 further.