J
Josep Marcos
Researcher at Pompeu Fabra University
Publications - 64
Citations - 2957
Josep Marcos is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Mass spectrometry & Metabolite. The author has an hindex of 29, co-authored 63 publications receiving 2628 citations. Previous affiliations of Josep Marcos include Analysis Group & Analytical Services.
Papers
More filters
Journal ArticleDOI
In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development
Masahiro Goto,Karen Piper Hanley,Josep Marcos,Peter J. Wood,Sarah Wright,Anthony D. Postle,Iain T. Cameron,J. Ian Mason,David I. Wilson,Neil A. Hanley +9 more
TL;DR: It is shown that the human fetal adrenal cortex synthesized cortisol much earlier than previously documented, an effect associated with transient expression of the orphan nuclear receptor nerve growth factor IB-like and its regulatory target, the steroidogenic enzyme type 2 3beta-hydroxysteroid dehydrogenase (HSD3B2).
Journal ArticleDOI
A novel pathway for sequential transformation of 7‐dehydrocholesterol and expression of the P450scc system in mammalian skin
Andrzej Slominski,Jordan K. Zjawiony,Jacobo Wortsman,Igor Semak,Jeremy Stewart,Alexander Pisarchik,Trevor W. Sweatman,Josep Marcos,Chuck Dunbar,Robert C. Tuckey +9 more
TL;DR: 7-DHC can form 7-DHP through P450scc side-chain cleavage, which may serve as a substrate for further conversions into hydroxy derivatives through existing steroidogenic enzymes, and has the potential to generate a variety of molecules depending on local steroidogenic activity and access to UVB.
Journal ArticleDOI
Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
Gareth G. Lavery,Gareth G. Lavery,Elizabeth A. Walker,Nicole Draper,Nicole Draper,Pancharatnam Jeyasuria,Josep Marcos,Cedric H.L. Shackleton,Keith L. Parker,Perrin C. White,Paul M. Stewart +10 more
TL;DR: The studies define the critical requirement of hexose-6-phosphate dehydrogenase for 11β-HSD1 oxoreductase activity and add a new dimension to the investigation of 11 β- HSD1 as a therapeutic target in patients with the metabolic syndrome.
Journal ArticleDOI
Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice.
Irene Gracia-Rubio,Maria Moscoso-Castro,Oscar J. Pozo,Josep Marcos,Roser Nadal,Olga Valverde +5 more
TL;DR: It is shown that adverse events during early life increase risk of long-lasting emotional alterations during adolescence and adulthood, and supports the preeminent role of neuroinflammation in emotional disorders.
Journal ArticleDOI
Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): A disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley–Bixler syndrome phenotype
TL;DR: It is proposed that excessive excretion of epiallopregnanediol together with low estriol may be prenatally diagnostic for OR deficiency (ORD), which is caused by mutations in P450 oxidoreductase (OR), the essential redox partner for CYP17 and CYP21 hydroxylases.